Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

John J. Treanor; Eveline L. Tierney; Suzanne L. Zebedee; Robert A. Lamb; Brian R. Murphy

Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

John J. Treanor^*, Eveline L. Tierney, Suzanne L. Zebedee, Robert A. Lamb, Brian R. Murphy

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

Original language	English (US)
Pages (from-to)	1375-1377
Number of pages	3
Journal	Journal of virology
Volume	64
Issue number	3
State	Published - 1990

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.",

author = "Treanor, {John J.} and Tierney, {Eveline L.} and Zebedee, {Suzanne L.} and Lamb, {Robert A.} and Murphy, {Brian R.}",

year = "1990",

language = "English (US)",

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journal = "Journal of virology",

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T1 - Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

AU - Treanor, John J.

AU - Tierney, Eveline L.

AU - Zebedee, Suzanne L.

AU - Lamb, Robert A.

AU - Murphy, Brian R.

PY - 1990

Y1 - 1990

N2 - The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

AB - The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

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Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

Abstract

ASJC Scopus subject areas

UN SDGs

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