Abstract
The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.
Original language | English (US) |
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Pages (from-to) | 1375-1377 |
Number of pages | 3 |
Journal | Journal of virology |
Volume | 64 |
Issue number | 3 |
State | Published - 1990 |
ASJC Scopus subject areas
- Insect Science
- Virology
- Microbiology
- Immunology