Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

J. J. Treanor*, E. L. Tierney, S. L. Zebedee, R. A. Lamb, B. R. Murphy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

192 Scopus citations

Abstract

The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62: 2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
JournalJournal of virology
Volume64
Issue number3
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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