Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

John J. Treanor*, Eveline L. Tierney, Suzanne L. Zebedee, Robert A. Lamb, Brian R. Murphy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

205 Scopus citations

Abstract

The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S. L. Zebedee and R. A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
JournalJournal of virology
Volume64
Issue number3
StatePublished - 1990

ASJC Scopus subject areas

  • Insect Science
  • Virology
  • Microbiology
  • Immunology

Fingerprint

Dive into the research topics of 'Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice'. Together they form a unique fingerprint.

Cite this