Patent ductus arteriosus in preterm infants: is early transcatheter closure a paradigm shift?

P. Vali*, S. Lakshminrusimha, A. Pelech, M. Underwood, F. Ing

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The optimal management approach of the patent ductus arteriosus (PDA) in premature infants remains uncertain owing the lack of evidence for long-term benefits and the limited analyses of the complications of medical and surgical interventions to date. In recent years, devices suitable to plug the PDA of premature infants (including extremely low birthweight, <1000 g) have become available and several trials have demonstrated successful and safe transcatheter PDA closure (TCPC) in this population. Whether TCPC represents a paradigm shift in PDA management that will result in improved short- and long-term outcomes, less bronchopulmonary dysplasia, improved neurodevelopment, or better long term renal function remains to be seen. Careful rigorous study of the potential benefits of TCPC in this highly vulnerable population in the context of well-designed adequately powered trials is needed prior to widespread adoption of this approach.

Original languageEnglish (US)
Pages (from-to)1449-1461
Number of pages13
JournalJournal of Perinatology
Issue number11
StatePublished - Nov 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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