TY - JOUR
T1 - Patent ductus arteriosus in preterm infants
T2 - is early transcatheter closure a paradigm shift?
AU - Vali, P.
AU - Lakshminrusimha, S.
AU - Pelech, A.
AU - Underwood, M.
AU - Ing, F.
N1 - Funding Information:
Funding The work has been supported by NIH grants HD096299 (PV) and HD072929 (SL).
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - The optimal management approach of the patent ductus arteriosus (PDA) in premature infants remains uncertain owing the lack of evidence for long-term benefits and the limited analyses of the complications of medical and surgical interventions to date. In recent years, devices suitable to plug the PDA of premature infants (including extremely low birthweight, <1000 g) have become available and several trials have demonstrated successful and safe transcatheter PDA closure (TCPC) in this population. Whether TCPC represents a paradigm shift in PDA management that will result in improved short- and long-term outcomes, less bronchopulmonary dysplasia, improved neurodevelopment, or better long term renal function remains to be seen. Careful rigorous study of the potential benefits of TCPC in this highly vulnerable population in the context of well-designed adequately powered trials is needed prior to widespread adoption of this approach.
AB - The optimal management approach of the patent ductus arteriosus (PDA) in premature infants remains uncertain owing the lack of evidence for long-term benefits and the limited analyses of the complications of medical and surgical interventions to date. In recent years, devices suitable to plug the PDA of premature infants (including extremely low birthweight, <1000 g) have become available and several trials have demonstrated successful and safe transcatheter PDA closure (TCPC) in this population. Whether TCPC represents a paradigm shift in PDA management that will result in improved short- and long-term outcomes, less bronchopulmonary dysplasia, improved neurodevelopment, or better long term renal function remains to be seen. Careful rigorous study of the potential benefits of TCPC in this highly vulnerable population in the context of well-designed adequately powered trials is needed prior to widespread adoption of this approach.
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U2 - 10.1038/s41372-019-0506-7
DO - 10.1038/s41372-019-0506-7
M3 - Review article
C2 - 31562396
AN - SCOPUS:85074010882
SN - 0743-8346
VL - 39
SP - 1449
EP - 1461
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -