Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status

John S. Esterly, Milena M. McLaughlin, Michael Malczynski, Chao Qi, Teresa R. Zembower, Marc H. Scheetz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).

Original languageEnglish (US)
Pages (from-to)1240-1242
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number2
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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