Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status

John S. Esterly; Milena M. McLaughlin; Michael Malczynski; Chao Qi; Teresa R. Zembower; Marc H. Scheetz

doi:10.1128/AAC.02201-13

Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status

John S. Esterly, Milena M. McLaughlin, Michael Malczynski, Chao Qi, Teresa R. Zembower, Marc H. Scheetz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).

Original language	English (US)
Pages (from-to)	1240-1242
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	2
DOIs	https://doi.org/10.1128/AAC.02201-13
State	Published - Feb 2014

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02201-13

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title = "Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status",

abstract = "Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).",

author = "Esterly, {John S.} and McLaughlin, {Milena M.} and Michael Malczynski and Chao Qi and Zembower, {Teresa R.} and Scheetz, {Marc H.}",

year = "2014",

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doi = "10.1128/AAC.02201-13",

language = "English (US)",

volume = "58",

pages = "1240--1242",

journal = "Antimicrobial agents and chemotherapy",

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publisher = "American Society for Microbiology",

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}

Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status. / Esterly, John S.; McLaughlin, Milena M.; Malczynski, Michael et al.
In: Antimicrobial agents and chemotherapy, Vol. 58, No. 2, 02.2014, p. 1240-1242.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status

AU - Esterly, John S.

AU - McLaughlin, Milena M.

AU - Malczynski, Michael

AU - Qi, Chao

AU - Zembower, Teresa R.

AU - Scheetz, Marc H.

PY - 2014/2

Y1 - 2014/2

N2 - Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).

AB - Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).

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JO - Antimicrobial agents and chemotherapy

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ER -

Pathogenicity of clinical Acinetobacter baumannii isolates in a galleria mellonella host model according to blaOXA-40 gene and epidemiological outbreak status

Abstract

ASJC Scopus subject areas

UN SDGs

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