Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh; Petra Houbova; Rudolph J. Castellani; Fausto J. Rodriguez; Minesh P. Mehta; Graeme F. Woodworth

doi:10.1016/j.jocn.2016.01.022

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh, Petra Houbova, Rudolph J. Castellani, Fausto J. Rodriguez, Minesh P. Mehta, Graeme F. Woodworth^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	30
DOIs	https://doi.org/10.1016/j.jocn.2016.01.022
State	Published - Aug 1 2016

Keywords

Amyloid
Immunoglobulin
Mass spectrometry

ASJC Scopus subject areas

Clinical Neurology
Neurology
Physiology (medical)
Surgery

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10.1016/j.jocn.2016.01.022

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title = "Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits",

abstract = "We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.",

keywords = "Amyloid, Immunoglobulin, Mass spectrometry",

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AU - Hersh, David S.

AU - Houbova, Petra

AU - Castellani, Rudolph J.

AU - Rodriguez, Fausto J.

AU - Mehta, Minesh P.

AU - Woodworth, Graeme F.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

AB - We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

KW - Amyloid

KW - Immunoglobulin

KW - Mass spectrometry

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JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

Abstract

Keywords

ASJC Scopus subject areas

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