Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh, Petra Houbova, Rudolph J. Castellani, Fausto J. Rodriguez, Minesh P. Mehta, Graeme F. Woodworth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalJournal of Clinical Neuroscience
Volume30
DOIs
StatePublished - Aug 1 2016

Keywords

  • Amyloid
  • Immunoglobulin
  • Mass spectrometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Surgery

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