Abstract
We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.
Original language | English (US) |
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Pages (from-to) | 143-145 |
Number of pages | 3 |
Journal | Journal of Clinical Neuroscience |
Volume | 30 |
DOIs | |
State | Published - Aug 1 2016 |
Keywords
- Amyloid
- Immunoglobulin
- Mass spectrometry
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Surgery