Abstract
Extensive disruptions of myofibrillar architecture or extensive areas of Z-band smearing occur in less than 2% of skeletal muscle fibers of the vastus lateralis muscle of untreated male Sprague-Dawley rats. Restraint for 2 hr, a potent stress in the rat, did not significantly increase the occurrence of extensive myofibrillar disruption, and acute or chronic administration of the potent psychotomimetic-anesthetic, phencyclidine, had only a slight effect on rat skeletal muscle morphology. However, phencyclidine plus restraint resulted in the occurrence of extensive areas of myofibrillar disruption and extensive Z-band smearing as well as scattered, segmental necrosis. Denervation of quadriceps femoris 40-48 hr prior to phencyclidine and restraint almost completely blocked the occurrence of any lesions. This suggests that intense muscle activity, with increased demand for and utilization of oxygen, can produce extensive architectural changes in skeletal muscle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 387-402 |
| Number of pages | 16 |
| Journal | Experimental Neurology |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1974 |
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ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
Cite this
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Pathologic effect of phencylidine and restraint on rat skeletal muscle structure : Prevention by prior denervation. / Kuncl, Ralph W.; Meltzer, Herbert Y.
In: Experimental Neurology, Vol. 45, No. 2, 11.1974, p. 387-402.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pathologic effect of phencylidine and restraint on rat skeletal muscle structure
T2 - Prevention by prior denervation
AU - Kuncl, Ralph W.
AU - Meltzer, Herbert Y.
PY - 1974/11
Y1 - 1974/11
N2 - Extensive disruptions of myofibrillar architecture or extensive areas of Z-band smearing occur in less than 2% of skeletal muscle fibers of the vastus lateralis muscle of untreated male Sprague-Dawley rats. Restraint for 2 hr, a potent stress in the rat, did not significantly increase the occurrence of extensive myofibrillar disruption, and acute or chronic administration of the potent psychotomimetic-anesthetic, phencyclidine, had only a slight effect on rat skeletal muscle morphology. However, phencyclidine plus restraint resulted in the occurrence of extensive areas of myofibrillar disruption and extensive Z-band smearing as well as scattered, segmental necrosis. Denervation of quadriceps femoris 40-48 hr prior to phencyclidine and restraint almost completely blocked the occurrence of any lesions. This suggests that intense muscle activity, with increased demand for and utilization of oxygen, can produce extensive architectural changes in skeletal muscle.
AB - Extensive disruptions of myofibrillar architecture or extensive areas of Z-band smearing occur in less than 2% of skeletal muscle fibers of the vastus lateralis muscle of untreated male Sprague-Dawley rats. Restraint for 2 hr, a potent stress in the rat, did not significantly increase the occurrence of extensive myofibrillar disruption, and acute or chronic administration of the potent psychotomimetic-anesthetic, phencyclidine, had only a slight effect on rat skeletal muscle morphology. However, phencyclidine plus restraint resulted in the occurrence of extensive areas of myofibrillar disruption and extensive Z-band smearing as well as scattered, segmental necrosis. Denervation of quadriceps femoris 40-48 hr prior to phencyclidine and restraint almost completely blocked the occurrence of any lesions. This suggests that intense muscle activity, with increased demand for and utilization of oxygen, can produce extensive architectural changes in skeletal muscle.
UR - http://www.scopus.com/inward/record.url?scp=0016276859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016276859&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(74)90127-7
DO - 10.1016/0014-4886(74)90127-7
M3 - Article
C2 - 4422846
AN - SCOPUS:0016276859
VL - 45
SP - 387
EP - 402
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -