TY - JOUR
T1 - Pathologic effect of phencylidine and restraint on rat skeletal muscle structure
T2 - Prevention by prior denervation
AU - Kuncl, Ralph W.
AU - Meltzer, Herbert Y.
N1 - Funding Information:
Phencyclidine (1-(phenylcyclohexyl)-piperidine HCl) is a dissociative inesthetic and psychotomimetic agent in man (21). In the rat, at a dose of j mg/kg, ip, phencyclidine produces a marked stimulation of locomotor activity. If the rat is restrained shortly after receiving the drugs, increases n plasma creatine phosphokinase (CPK) activity of 100 times normal develop within 2 hr (23). These increases in plasma CPK activity are lighly correlated with muscle tension developed during the restraint period (11) . Significant changes develop in rat skeletal muscle cytoarchitecture 1 Dr. Kuncl was supported by USPHS Training Grant 5T05 GM01939-OS-MSTP. rhis research was financed by USPHS grant 5ROl MH-18. 396; State of Illinois grant 431-13-RD, and Career Development Award USPHS MH-47, 808. The authors wish to acknowledge their appreciation to Ann Whitlatch for assistance in prepara-ion of the manuscript and to Eleanor McBride for technical assistance.
PY - 1974/11
Y1 - 1974/11
N2 - Extensive disruptions of myofibrillar architecture or extensive areas of Z-band smearing occur in less than 2% of skeletal muscle fibers of the vastus lateralis muscle of untreated male Sprague-Dawley rats. Restraint for 2 hr, a potent stress in the rat, did not significantly increase the occurrence of extensive myofibrillar disruption, and acute or chronic administration of the potent psychotomimetic-anesthetic, phencyclidine, had only a slight effect on rat skeletal muscle morphology. However, phencyclidine plus restraint resulted in the occurrence of extensive areas of myofibrillar disruption and extensive Z-band smearing as well as scattered, segmental necrosis. Denervation of quadriceps femoris 40-48 hr prior to phencyclidine and restraint almost completely blocked the occurrence of any lesions. This suggests that intense muscle activity, with increased demand for and utilization of oxygen, can produce extensive architectural changes in skeletal muscle.
AB - Extensive disruptions of myofibrillar architecture or extensive areas of Z-band smearing occur in less than 2% of skeletal muscle fibers of the vastus lateralis muscle of untreated male Sprague-Dawley rats. Restraint for 2 hr, a potent stress in the rat, did not significantly increase the occurrence of extensive myofibrillar disruption, and acute or chronic administration of the potent psychotomimetic-anesthetic, phencyclidine, had only a slight effect on rat skeletal muscle morphology. However, phencyclidine plus restraint resulted in the occurrence of extensive areas of myofibrillar disruption and extensive Z-band smearing as well as scattered, segmental necrosis. Denervation of quadriceps femoris 40-48 hr prior to phencyclidine and restraint almost completely blocked the occurrence of any lesions. This suggests that intense muscle activity, with increased demand for and utilization of oxygen, can produce extensive architectural changes in skeletal muscle.
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U2 - 10.1016/0014-4886(74)90127-7
DO - 10.1016/0014-4886(74)90127-7
M3 - Article
C2 - 4422846
AN - SCOPUS:0016276859
VL - 45
SP - 387
EP - 402
JO - Neurodegeneration
JF - Neurodegeneration
SN - 0014-4886
IS - 2
ER -