Pathological calcifications studied with microCT

Stuart R Stock*, N. M. Rajamannan, E. R. Brooks, Craig Langman, Lauren M Pachman

*Corresponding author for this work

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

Original languageEnglish (US)
Article number45
Pages (from-to)424-431
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5535
DOIs
StatePublished - Dec 1 2004
EventDevelopments in X-Ray Tomography IV - Denver, CO, United States
Duration: Aug 4 2004Aug 6 2004

Fingerprint

Micro-CT
calcification
rabbits
Rabbit
Microstructure
renal calculi
Deposits
deposits
kidney stones
blueprints
rocks
Blueprints
diets
microstructure
Kidney
Nutrition
Microscopy
numerical analysis
Numerical analysis
Numerical Analysis

Keywords

  • Blood vessel calcification
  • Calcification
  • Juvenile dermatomyositis
  • Kidney stones
  • MicroCT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

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title = "Pathological calcifications studied with microCT",
abstract = "The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.",
keywords = "Blood vessel calcification, Calcification, Juvenile dermatomyositis, Kidney stones, MicroCT",
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Pathological calcifications studied with microCT. / Stock, Stuart R; Rajamannan, N. M.; Brooks, E. R.; Langman, Craig; Pachman, Lauren M.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 5535, 45, 01.12.2004, p. 424-431.

Research output: Contribution to journalConference article

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