Pathological calcifications studied with microCT

Stuart R Stock*, N. M. Rajamannan, E. R. Brooks, Craig Langman, Lauren M Pachman

*Corresponding author for this work

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

Original languageEnglish (US)
Article number45
Pages (from-to)424-431
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5535
DOIs
StatePublished - Dec 1 2004
EventDevelopments in X-Ray Tomography IV - Denver, CO, United States
Duration: Aug 4 2004Aug 6 2004

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Keywords

  • Blood vessel calcification
  • Calcification
  • Juvenile dermatomyositis
  • Kidney stones
  • MicroCT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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