Pathological calcifications studied with microCT

S. R. Stock; N. M. Rajamannan; E. R. Brooks; C. B. Langman; L. M. Pachman

doi:10.1117/12.560466

Pathological calcifications studied with microCT

S. R. Stock^*, N. M. Rajamannan, E. R. Brooks, C. B. Langman, L. M. Pachman

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

Original language	English (US)
Article number	45
Pages (from-to)	424-431
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5535
DOIs	https://doi.org/10.1117/12.560466
State	Published - 2004
Event	Developments in X-Ray Tomography IV - Denver, CO, United States Duration: Aug 4 2004 → Aug 6 2004

Keywords

Blood vessel calcification
Calcification
Juvenile dermatomyositis
Kidney stones
MicroCT

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.560466

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title = "Pathological calcifications studied with microCT",

abstract = "The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.",

keywords = "Blood vessel calcification, Calcification, Juvenile dermatomyositis, Kidney stones, MicroCT",

author = "Stock, {S. R.} and Rajamannan, {N. M.} and Brooks, {E. R.} and Langman, {C. B.} and Pachman, {L. M.}",

year = "2004",

doi = "10.1117/12.560466",

language = "English (US)",

volume = "5535",

pages = "424--431",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Developments in X-Ray Tomography IV ; Conference date: 04-08-2004 Through 06-08-2004",

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AU - Stock, S. R.

AU - Rajamannan, N. M.

AU - Brooks, E. R.

AU - Langman, C. B.

AU - Pachman, L. M.

PY - 2004

Y1 - 2004

N2 - The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

AB - The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

KW - Blood vessel calcification

KW - Calcification

KW - Juvenile dermatomyositis

KW - Kidney stones

KW - MicroCT

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DO - 10.1117/12.560466

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

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Y2 - 4 August 2004 through 6 August 2004

ER -

Pathological calcifications studied with microCT

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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