Pathophysiology of Contrast-Induced Nephropathy

James Tumlin*, Fulvio Stacul, Andy Adam, Christoph R. Becker, Charles Davidson, Norbert Lameire, Peter A. McCullough

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

293 Scopus citations

Abstract

Contrast-induced nephropathy (CIN) is the third leading cause of acute kidney injury in hospitalized patients and is associated with significant patient morbidity. The pathogenesis of CIN is complex and not fully understood, but iodinated contrast agents induce intense and prolonged vasoconstriction at the corticomedullary junction of the kidney. Moreover, high-osmolar dyes directly impair the autoregulatory capacity of the kidney through a loss of nitric oxide production. These effects, coupled with direct tubular toxicity of contrast media, lead to overt acute tubular necrosis and the syndrome of CIN.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalAmerican Journal of Cardiology
Volume98
Issue number6 SUPPL. 1
DOIs
StatePublished - Sep 18 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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