Pathophysiology of Muscle Contractures in Cerebral Palsy

Margie A. Mathewson, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Patients with cerebral palsy present with a variety of adaptations to muscle structure and function. These pathophysiologic symptoms include functional deficits such as decreased force production and range of motion, in addition to changes in muscle structure such as decreased muscle belly size, increased sarcomere length, and altered extracellular matrix structure and composition. On a cellular level, patients with cerebral palsy have fewer muscle stem cells, termed satellite cells, and altered gene expression. Understanding the nature of these changes may present opportunities for the development of new muscle treatment therapies.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number1
StatePublished - Feb 1 2015


  • Cerebral palsy
  • Extracellular matrix
  • Fiber
  • Gene expression
  • Pathophysiology
  • Sarcomere
  • Skeletal muscle

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation


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