Pathways for the response of the eye to injury

L. M. Jampol, A. H. Neufeld, M. L. Sears

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The role of a neural pathway in the disruption of the blood aqueous barrier of the rabbit after 2 irritating stimuli, topical nitrogen mustard, and paracentesis, was studied. Retrobulbar anesthesia or section of the ophthalmic division of the trigeminal nerve decreased the breakdown of the blood aqueous barrier, as measured by protein in the aqueous humor, after topical nitrogen mustard. Sensory denervation, accomplished with retrobulbar alcohol, virtually prevented the protein rise in the aqueous humor. Disruption of the blood aqueous barrier after paracentesis, however, was not affected by retrobulbar anesthesia or alcohol denervation. Therefore, the increased protein in the aqueous humor after an irritative stimulus appears to be mediated by at least 2 pathways. The response to a stimulus such as nitrogen mustard depends on sensory innervation and is not mediated by prostaglandins to any important degree. The response to paracentesis does not require sensory innervation and appears to be mediated, at least in part, by prostaglandins.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalInvestigative Ophthalmology
Issue number3
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Medicine(all)


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