Formation osseuse, facteurs de régulation

Translated title of the contribution: Pathways regulating bone formation: A complex network

Thierry Thomas*, Aline Martin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Bone tissue undergoes permanent remodeling based on the coupled activity of osteoclasts resorbing old bone and osteoblasts forming a new matrix. The latter are considered as the main target of remodeling control pathways. Indeed, they have the full control of osteoclastogenesis through RANK-L / osteoprotegerin, the most critical pathway in the balance between bone formation and resorption. They also are under the effects of numerous transcription factors, especially members of the AP1 complex as well as the canonic Wnt - βcatenin pathway. Most bone tissue pathologies are mediated by alterations of these remodeling control pathways. Therefore, lots of efforts are made to modulate these factors which are very interesting potential therapeutic targets.

Translated title of the contributionPathways regulating bone formation: A complex network
Original languageFrench
Pages (from-to)257-264
Number of pages8
JournalJournal de la Societe de Biologie
Volume202
Issue number4
DOIs
StatePublished - Dec 1 2008

Keywords

  • Bone matrix
  • Bone remodeling
  • Cytokines
  • Loading
  • Osteoblast

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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