TY - JOUR
T1 - Pathways to Neuroprediction
T2 - Opportunities and Challenges to Prediction of Treatment Response in Depression
AU - Langenecker, Scott A.
AU - Crane, Natania A.
AU - Jenkins, Lisanne M.
AU - Phan, K. Luan
AU - Klumpp, Heide
N1 - Funding Information:
Support for this work was provided by MH101487 (SAL, LMJ. KLP, NAC), MH101497 (KLP, HK, SAL), MH112705 (HK, SAL, KLP), T32 MH067631 (NAC, Rasenick Pi).
Funding Information:
The authors have received grant money from the National Institute of Mental Health.
Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose of Review: We set out to review the current state of science in neuroprediction, using biological measures of brain function, with task based fMRI to prospectively predict response to a variety of treatments. Recent Findings: Task-based fMRI neuroprediction studies are balanced between whole brain and ROI specific analyses. The predominant tasks are emotion processing, with ROIs based upon amygdala and subgenual anterior cingulate gyrus, both within the salience and emotion network. A rapidly emerging new area of neuroprediction is of disease course and illness recurrence. Concerns include use of open-label and single arm studies, lack of consideration of placebo effects, unbalanced adjustments for multiple comparisons (over focus on type I error), small sample sizes, unreported effect sizes, overreliance on ROI studies. Summary: There is a need to adjust neuroprediction study reporting so that greater coherence can facilitate meta analyses, and increased funding for more multiarm studies in neuroprediction.
AB - Purpose of Review: We set out to review the current state of science in neuroprediction, using biological measures of brain function, with task based fMRI to prospectively predict response to a variety of treatments. Recent Findings: Task-based fMRI neuroprediction studies are balanced between whole brain and ROI specific analyses. The predominant tasks are emotion processing, with ROIs based upon amygdala and subgenual anterior cingulate gyrus, both within the salience and emotion network. A rapidly emerging new area of neuroprediction is of disease course and illness recurrence. Concerns include use of open-label and single arm studies, lack of consideration of placebo effects, unbalanced adjustments for multiple comparisons (over focus on type I error), small sample sizes, unreported effect sizes, overreliance on ROI studies. Summary: There is a need to adjust neuroprediction study reporting so that greater coherence can facilitate meta analyses, and increased funding for more multiarm studies in neuroprediction.
KW - Cognitive behavioral therapy
KW - Depression
KW - Networks
KW - Prediction
KW - Psychopharmacology
KW - fMRI
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UR - http://www.scopus.com/inward/citedby.url?scp=85045467808&partnerID=8YFLogxK
U2 - 10.1007/s40473-018-0140-2
DO - 10.1007/s40473-018-0140-2
M3 - Review article
AN - SCOPUS:85045467808
SN - 2196-2979
VL - 5
SP - 48
EP - 60
JO - Current Behavioral Neuroscience Reports
JF - Current Behavioral Neuroscience Reports
IS - 1
ER -
