Patient and tumor characteristics associated with increased mortality in young women (≤40 years) with breast cancer

Ankit Bharat, Rebecca L. Aft, Feng Gao, Julie A. Margenthaler

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Background: The goal of the current study is to identify predictors responsible for mortality disparities between young (≤40 years) and older (>40 years) women with breast cancer. Methods: From 1998 to 2006, 344 patients ≤40 years were treated for breast cancer. Cox regression models calculated adjusted hazard ratios (aHR) and 95% confidence intervals (CI) to determine differences in breast cancer mortality in women ≤40 years versus >40 years (n = 3,252), controlling for potential confounders in univariate tests. Results: From 1998 to 2006, 3,596 patients were treated for breast cancer; 9.6% were ≤40 years and 90.4% were >40 years. Young women were more likely to be African-American, with a family history of breast cancer, diagnosed at advanced stage, and treated by mastectomy (P < 0.05). Tumors in young women were more likely to be bilateral, T2/T3, grade III, ER/PR negative, and lymph-node positive (P < 0.01). Overall, young women (≤40 years) with breast cancer were more likely to die compared with older women (>40 years) (aHR 1.52, CI 1.37-1.74). Conclusions: Young women (≤40 years) with breast cancer are diagnosed at a more advanced stage and have tumors with poor prognostic features. Young women (≤40 years) are 52% more likely to die from breast cancer compared to older women (>40 years).

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalJournal of surgical oncology
Volume100
Issue number3
DOIs
StatePublished - Sep 24 2009

Keywords

  • Breast cancer
  • Mortality
  • Young age (≤40 years)

ASJC Scopus subject areas

  • Surgery
  • Oncology

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