Patient characteristics associated with more bother from lower urinary tract symptoms

Alice B. Liu; Qian Liu; Claire C. Yang; James W. Griffith; Abigail R. Smith; Margaret E. Helmuth; H. Henry Lai; Cindy L. Amundsen; Bradley A. Erickson; J. Eric Jelovsek; Nnenaya Q. Agochukwu; Margaret G. Mueller; Victor P. Andreev; Kevin P. Weinfurt; Kimberly S. Kenton; Matthew O. Fraser; Anne P. Cameron; Ziya Kirkali; John L. Gore

doi:10.1097/JU.0000000000000324

Patient characteristics associated with more bother from lower urinary tract symptoms

Alice B. Liu^*, Qian Liu, Claire C. Yang, James W. Griffith, Abigail R. Smith, Margaret E. Helmuth, H. Henry Lai, Cindy L. Amundsen, Bradley A. Erickson, J. Eric Jelovsek, Nnenaya Q. Agochukwu, Margaret G. Mueller, Victor P. Andreev, Kevin P. Weinfurt, Kimberly S. Kenton, Matthew O. Fraser, Anne P. Cameron, Ziya Kirkali, John L. Gore

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Purpose: Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. Materials and Methods: In this 1-year prospective, observational cohort study we obtained data on patients with lower urinary tract symptoms who were seeking care at a total of 6 tertiary care centers in the United States. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and 1,2 months later. Multilevel logistic and linear regression was used to identify factors associated with worsening bother and bother at 1,2 months, respectively. Results: Of the 756 participants 1,21 (16%) had worsened lower urinary tract symptom bother during the study period. When adjusted for other variables, worsened lower urinary tract symptom bother was more likely among men who were nonwhite (OR 1.79, 95% CI 0.94e3.40) or who had diabetes (OR 1.68, 95% CI 0.86e3.27) and among women with diabetes (OR 1.77, 95% CI 0.85e3.67), prior treatment of lower urinary tract symptoms (OR 2.58, 95% CI 1.22e5.46) or a higher depression level (OR 1.29, 95% CI 1.10e1.52). Baseline factors associated with more severe bother at 1,2 months in men included more severe bother at baseline, nonwhite race, worse urinary frequency and incontinence, and, higher levels of stress (p <0.05). Among women more severe bother at baseline, urinary urgency and frequency, and worse physical function were associated with more severe bother at 1,2 months. Conclusions: Urinary symptom severity at baseline, race, depression and psychological stress were associated with the bother of lower urinary tract symptoms in a prospective cohort of men and women treated at tertiary care facilities. These findings may inform the clinical care of patients with bothersome lower urinary tract symptoms and direct providers to better prognosticate for patients with challenging lower urinary tract symptoms cases.

Original language	English (US)
Pages (from-to)	585-591
Number of pages	7
Journal	Journal of Urology
Volume	202
Issue number	3
DOIs	https://doi.org/10.1097/JU.0000000000000324
State	Published - Sep 2019

Funding

Keywords

Lower urinary tract symptoms
Patient reported outcome measures
Population characteristics
Prognosis
Urinary bladder

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JU.0000000000000324

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Liu, A. B., Liu, Q., Yang, C. C., Griffith, J. W., Smith, A. R., Helmuth, M. E., Lai, H. H., Amundsen, C. L., Erickson, B. A., Jelovsek, J. E., Agochukwu, N. Q., Mueller, M. G., Andreev, V. P., Weinfurt, K. P., Kenton, K. S., Fraser, M. O., Cameron, A. P., Kirkali, Z., & Gore, J. L. (2019). Patient characteristics associated with more bother from lower urinary tract symptoms. Journal of Urology, 202(3), 585-591. https://doi.org/10.1097/JU.0000000000000324

@article{63042047927041a8b626cc75624fe2d8,

title = "Patient characteristics associated with more bother from lower urinary tract symptoms",

abstract = "Purpose: Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. Materials and Methods: In this 1-year prospective, observational cohort study we obtained data on patients with lower urinary tract symptoms who were seeking care at a total of 6 tertiary care centers in the United States. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and 1,2 months later. Multilevel logistic and linear regression was used to identify factors associated with worsening bother and bother at 1,2 months, respectively. Results: Of the 756 participants 1,21 (16%) had worsened lower urinary tract symptom bother during the study period. When adjusted for other variables, worsened lower urinary tract symptom bother was more likely among men who were nonwhite (OR 1.79, 95% CI 0.94e3.40) or who had diabetes (OR 1.68, 95% CI 0.86e3.27) and among women with diabetes (OR 1.77, 95% CI 0.85e3.67), prior treatment of lower urinary tract symptoms (OR 2.58, 95% CI 1.22e5.46) or a higher depression level (OR 1.29, 95% CI 1.10e1.52). Baseline factors associated with more severe bother at 1,2 months in men included more severe bother at baseline, nonwhite race, worse urinary frequency and incontinence, and, higher levels of stress (p <0.05). Among women more severe bother at baseline, urinary urgency and frequency, and worse physical function were associated with more severe bother at 1,2 months. Conclusions: Urinary symptom severity at baseline, race, depression and psychological stress were associated with the bother of lower urinary tract symptoms in a prospective cohort of men and women treated at tertiary care facilities. These findings may inform the clinical care of patients with bothersome lower urinary tract symptoms and direct providers to better prognosticate for patients with challenging lower urinary tract symptoms cases.",

keywords = "Lower urinary tract symptoms, Patient reported outcome measures, Population characteristics, Prognosis, Urinary bladder",

author = "Liu, {Alice B.} and Qian Liu and Yang, {Claire C.} and Griffith, {James W.} and Smith, {Abigail R.} and Helmuth, {Margaret E.} and Lai, {H. Henry} and Amundsen, {Cindy L.} and Erickson, {Bradley A.} and Jelovsek, {J. Eric} and Agochukwu, {Nnenaya Q.} and Mueller, {Margaret G.} and Andreev, {Victor P.} and Weinfurt, {Kevin P.} and Kenton, {Kimberly S.} and Fraser, {Matthew O.} and Cameron, {Anne P.} and Ziya Kirkali and Gore, {John L.}",

note = "Publisher Copyright: {\textcopyright} 2019 by American UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.",

year = "2019",

month = sep,

doi = "10.1097/JU.0000000000000324",

language = "English (US)",

volume = "202",

pages = "585--591",

journal = "Journal of Urology",

issn = "0022-5347",

publisher = "Elsevier Inc.",

number = "3",

}

Liu, AB, Liu, Q, Yang, CC, Griffith, JW, Smith, AR, Helmuth, ME, Lai, HH, Amundsen, CL, Erickson, BA, Jelovsek, JE, Agochukwu, NQ, Mueller, MG, Andreev, VP, Weinfurt, KP, Kenton, KS, Fraser, MO, Cameron, AP, Kirkali, Z & Gore, JL 2019, 'Patient characteristics associated with more bother from lower urinary tract symptoms', Journal of Urology, vol. 202, no. 3, pp. 585-591. https://doi.org/10.1097/JU.0000000000000324

TY - JOUR

T1 - Patient characteristics associated with more bother from lower urinary tract symptoms

AU - Liu, Alice B.

AU - Liu, Qian

AU - Yang, Claire C.

AU - Griffith, James W.

AU - Smith, Abigail R.

AU - Helmuth, Margaret E.

AU - Lai, H. Henry

AU - Amundsen, Cindy L.

AU - Erickson, Bradley A.

AU - Jelovsek, J. Eric

AU - Agochukwu, Nnenaya Q.

AU - Mueller, Margaret G.

AU - Andreev, Victor P.

AU - Weinfurt, Kevin P.

AU - Kenton, Kimberly S.

AU - Fraser, Matthew O.

AU - Cameron, Anne P.

AU - Kirkali, Ziya

AU - Gore, John L.

PY - 2019/9

Y1 - 2019/9

N2 - Purpose: Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. Materials and Methods: In this 1-year prospective, observational cohort study we obtained data on patients with lower urinary tract symptoms who were seeking care at a total of 6 tertiary care centers in the United States. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and 1,2 months later. Multilevel logistic and linear regression was used to identify factors associated with worsening bother and bother at 1,2 months, respectively. Results: Of the 756 participants 1,21 (16%) had worsened lower urinary tract symptom bother during the study period. When adjusted for other variables, worsened lower urinary tract symptom bother was more likely among men who were nonwhite (OR 1.79, 95% CI 0.94e3.40) or who had diabetes (OR 1.68, 95% CI 0.86e3.27) and among women with diabetes (OR 1.77, 95% CI 0.85e3.67), prior treatment of lower urinary tract symptoms (OR 2.58, 95% CI 1.22e5.46) or a higher depression level (OR 1.29, 95% CI 1.10e1.52). Baseline factors associated with more severe bother at 1,2 months in men included more severe bother at baseline, nonwhite race, worse urinary frequency and incontinence, and, higher levels of stress (p <0.05). Among women more severe bother at baseline, urinary urgency and frequency, and worse physical function were associated with more severe bother at 1,2 months. Conclusions: Urinary symptom severity at baseline, race, depression and psychological stress were associated with the bother of lower urinary tract symptoms in a prospective cohort of men and women treated at tertiary care facilities. These findings may inform the clinical care of patients with bothersome lower urinary tract symptoms and direct providers to better prognosticate for patients with challenging lower urinary tract symptoms cases.

AB - Purpose: Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. Materials and Methods: In this 1-year prospective, observational cohort study we obtained data on patients with lower urinary tract symptoms who were seeking care at a total of 6 tertiary care centers in the United States. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and 1,2 months later. Multilevel logistic and linear regression was used to identify factors associated with worsening bother and bother at 1,2 months, respectively. Results: Of the 756 participants 1,21 (16%) had worsened lower urinary tract symptom bother during the study period. When adjusted for other variables, worsened lower urinary tract symptom bother was more likely among men who were nonwhite (OR 1.79, 95% CI 0.94e3.40) or who had diabetes (OR 1.68, 95% CI 0.86e3.27) and among women with diabetes (OR 1.77, 95% CI 0.85e3.67), prior treatment of lower urinary tract symptoms (OR 2.58, 95% CI 1.22e5.46) or a higher depression level (OR 1.29, 95% CI 1.10e1.52). Baseline factors associated with more severe bother at 1,2 months in men included more severe bother at baseline, nonwhite race, worse urinary frequency and incontinence, and, higher levels of stress (p <0.05). Among women more severe bother at baseline, urinary urgency and frequency, and worse physical function were associated with more severe bother at 1,2 months. Conclusions: Urinary symptom severity at baseline, race, depression and psychological stress were associated with the bother of lower urinary tract symptoms in a prospective cohort of men and women treated at tertiary care facilities. These findings may inform the clinical care of patients with bothersome lower urinary tract symptoms and direct providers to better prognosticate for patients with challenging lower urinary tract symptoms cases.

KW - Lower urinary tract symptoms

KW - Patient reported outcome measures

KW - Population characteristics

KW - Prognosis

KW - Urinary bladder

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UR - http://www.scopus.com/inward/citedby.url?scp=85071347500&partnerID=8YFLogxK

U2 - 10.1097/JU.0000000000000324

DO - 10.1097/JU.0000000000000324

M3 - Article

C2 - 31063049

AN - SCOPUS:85071347500

SN - 0022-5347

VL - 202

SP - 585

EP - 591

JO - Journal of Urology

JF - Journal of Urology

IS - 3

ER -

Patient characteristics associated with more bother from lower urinary tract symptoms

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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