Patient factors associated with sperm cryopreservation among at-risk adolescents newly diagnosed with cancer

James L. Klosky*, Vicky Lehmann, Jessica S. Flynn, Yin Su, Hui Zhang, Kathryn M. Russell, Lauren A.M. Schenck, Leslie R. Schover

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

BACKGROUND: Although survivors of adolescent-onset cancers are at risk of infertility, the majority desire children. Fertility preservation options are available for adolescents, but sperm banking remains underused. To the authors' knowledge, patient factors that influence decisions to bank sperm are poorly understood. METHODS: A cross-sectional study of 146 adolescent males who were newly diagnosed with cancer and who completed surveys within 1 week of treatment initiation was performed. Participants, 65% of whom were white, were aged 13 to 21 years (mean, 16.49 years; standard deviation, 2.02 years) and were at risk of infertility secondary to impending gonadotoxic treatment. Participating institutions included 8 leading pediatric oncology centers across the United States and Canada. RESULTS: Of the patients approached, approximately 80.6% participated. Parent recommendation to bank (odds ratio [OR], 4.88; 95% confidence interval [95% CI], 1.15-20.71 [P =.03]), higher Tanner stage (OR, 4.25; 95% CI, 1.60-11.27 [P <.01]), greater perceived benefits (OR, 1.41; 95% CI, 1.12-1.77 [P <.01]), and lower social barriers to banking (OR, 0.88; 95% CI, 0.81-0.96 [P <.01]) were found to be associated with adolescent collection attempts, whereas meeting with a fertility specialist (OR, 3.44; 95% CI, 1.00-11.83 [P =.05]), parent (OR, 3.02; 95% CI, 1.12-8.10 [P =.03]) or provider (OR, 2.67; 95% CI, 1.05-6.77 [P =.04]) recommendation to bank, and greater adolescent self-efficacy to bank (OR, 1.16; 95% CI, 1.01-1.33 [P =.03]) were found to be associated with successful sperm banking. CONCLUSIONS: Adolescents' perceived benefits of sperm banking, higher Tanner stage, and parent recommendation were associated with collection attempts, whereas perceived social barriers decreased this likelihood. Successful banking was associated with greater adolescent self-efficacy, parent and provider recommendation to bank, and consultation with a fertility specialist. Providers should consult with both adolescents and parents regarding fertility preservation, and interventions should be tailored to address barriers to sperm banking while promoting its benefits.

Original languageEnglish (US)
Pages (from-to)3567-3575
Number of pages9
JournalCancer
Volume124
Issue number17
DOIs
StatePublished - Sep 1 2018

Keywords

  • adolescent
  • cryopreservation
  • male infertility
  • oncology
  • psychology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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