Patient reported outcomes in patients with head and neck cancer treated with concurrent chemoradiation with weekly versus bolus cisplatin

Mona Arbab, Yu Hui Chen, Shana Criscitiello, Jason Glass, Jo Ann Fugazzotto, Joseph H. Killoran, Glenn Hanna, Jochen Lorch, Robert I. Haddad, Danielle N. Margalit, Roy B. Tishler, Jonathan D. Schoenfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Patient Reported Outcome (PRO) data comparing bolus (B-CP) with weekly (W-CP) cisplatin concurrent with radiation are lacking. Methods: We performed a retrospective study comparing PRO among 99 patients with head and neck radiation, 26% who received concurrent B-CP and 73% treated with W-CP. Results: W-CP patients had a higher Charlson comorbidity index (CCI) (P =.004). There were no differences in median cisplatin dose, PROs, percutaneous endoscopic gastrostomy (PEG) dependence or hospitalization between arms. Patients with a greater decline in their self-reported dysphagia score were more often PEG dependent at the end of radiation therapy (P =.03). There was also a trend toward PEG dependence with a higher maximum dysphagia score and greater change in aspiration score (P =.06). The maximum decline in white cell count and absolute neutrophil count were greater in the W-CP group (P =.04, P =.01). Conclusion: Both B-CP and W-CP are well tolerated. PROs do not suggest a benefit to W-CP.

Original languageEnglish (US)
Pages (from-to)3670-3677
Number of pages8
JournalHead and Neck
Volume42
Issue number12
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • bolus cisplatin
  • chemoradiation
  • head and neck cancer
  • patient reported outcome
  • weekly cisplatin

ASJC Scopus subject areas

  • Otorhinolaryngology

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