Patient satisfaction with budesonide Turbuhaler™ versus triamcinolone acetonide administered via pressurized metered-dose inhaler in a managed care setting

Kevin B Weiss, L. Clark Paramore*, Bengt Liljas, Dennis A. Revicki, Bryan R. Luce

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Dissatisfaction with medication may negatively affect compliance and thus the effectiveness of the treatment. However, no prospective well-controlled studies have assessed the relative patient satisfaction with competing inhaled corticosteroids in a real-life setting. The objective of the current study was to compare the relative patient satisfaction with budesonide inhalation powder administered via Turbuhaler (AstraZeneca LP, Wilmington, DE) (200 to 1600 μg/d using one of 3 dosing strengths: 100, 200, or 400 μg per inhalation) and triamcinolone acetonide administered via pressurized metered-dose inhaler (200 to 1600 μg/d) among persons treated in managed care settings. A total of 945 subjects 18 years of age or older diagnosed with asthma and enrolled in 25 managed care organizations participated in this prospective, randomized, open-label, parallel-group, 12-month study. As part of the study, subjects completed a self-administered, 17-item patient satisfaction questionnaire that addressed 4 domains: side effects, knowledge/ease of use, convenience, and overall satisfaction. Questionnaire reliability was assessed using Cronbach's alpha, and validity was examined by correlating subscale scores with symptom-free days and Medical Outcomes Study 36-Item Short-Form questionnaire and Asthma Quality of Life Questionnaire scores. The satisfaction questionnaire also included a previously validated section addressing patient compliance. Patients receiving budesonide had significantly higher scores for all four satisfaction subscales throughout the study period than did those receiving triamcinolone acetonide. Similarly, compliance scores were consistently higher for the budesonide group. The difference between the treatment groups in overall satisfaction scores at the end of the study was clinically meaningful. Patients treated with budesonide were significantly more satisfied and compliant with their inhaled corticosteroid regimen compared with patients treated with triamcinolone acetonide.

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalJournal of Asthma
Volume42
Issue number9
DOIs
StatePublished - Oct 1 2005

Keywords

  • Asthma
  • Budesonide
  • Compliance
  • Inhaled corticosteroids
  • Managed care setting
  • Patient satisfaction
  • Real life
  • Triamcinolone acetonide

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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