TY - JOUR
T1 - Patient satisfaction with budesonide Turbuhaler™ versus triamcinolone acetonide administered via pressurized metered-dose inhaler in a managed care setting
AU - Weiss, Kevin B.
AU - Paramore, L. Clark
AU - Liljas, Bengt
AU - Revicki, Dennis A.
AU - Luce, Bryan R.
N1 - Funding Information:
Supported by AstraZeneca LP, Wilmington, Delaware. *Corresponding author: L. Clark Paramore, M.S.P.H., The MEDTAP Institute at United BioSource Corporation, 7101 Wisconsin Ave., Suite 600, Bethesda, MD 20814, USA; Fax: (301) 654-9864; E-mail: clark.paramore@unitedbiosource.com
Funding Information:
ACKNOWLEDGMENTS This work was funded by AstraZeneca LP, formerly Astra Pharmaceuticals LP. Michael Neidl, Ellen Dukes, and Anna Lisa Raymundo, formerly of Astra Pharmaceuticals LP, played a significant role in the initial development of the questionnaire. Nancy Kline Leidy, Ph.D., of The MEDTAP Institute at United BioSource Corporation, provided valuable input on questionnaire assessment. Leslie Sell (Thomson Scientific Connexions, Newtown, PA) provided editorial assistance.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/10
Y1 - 2005/10
N2 - Dissatisfaction with medication may negatively affect compliance and thus the effectiveness of the treatment. However, no prospective well-controlled studies have assessed the relative patient satisfaction with competing inhaled corticosteroids in a real-life setting. The objective of the current study was to compare the relative patient satisfaction with budesonide inhalation powder administered via Turbuhaler (AstraZeneca LP, Wilmington, DE) (200 to 1600 μg/d using one of 3 dosing strengths: 100, 200, or 400 μg per inhalation) and triamcinolone acetonide administered via pressurized metered-dose inhaler (200 to 1600 μg/d) among persons treated in managed care settings. A total of 945 subjects 18 years of age or older diagnosed with asthma and enrolled in 25 managed care organizations participated in this prospective, randomized, open-label, parallel-group, 12-month study. As part of the study, subjects completed a self-administered, 17-item patient satisfaction questionnaire that addressed 4 domains: side effects, knowledge/ease of use, convenience, and overall satisfaction. Questionnaire reliability was assessed using Cronbach's alpha, and validity was examined by correlating subscale scores with symptom-free days and Medical Outcomes Study 36-Item Short-Form questionnaire and Asthma Quality of Life Questionnaire scores. The satisfaction questionnaire also included a previously validated section addressing patient compliance. Patients receiving budesonide had significantly higher scores for all four satisfaction subscales throughout the study period than did those receiving triamcinolone acetonide. Similarly, compliance scores were consistently higher for the budesonide group. The difference between the treatment groups in overall satisfaction scores at the end of the study was clinically meaningful. Patients treated with budesonide were significantly more satisfied and compliant with their inhaled corticosteroid regimen compared with patients treated with triamcinolone acetonide.
AB - Dissatisfaction with medication may negatively affect compliance and thus the effectiveness of the treatment. However, no prospective well-controlled studies have assessed the relative patient satisfaction with competing inhaled corticosteroids in a real-life setting. The objective of the current study was to compare the relative patient satisfaction with budesonide inhalation powder administered via Turbuhaler (AstraZeneca LP, Wilmington, DE) (200 to 1600 μg/d using one of 3 dosing strengths: 100, 200, or 400 μg per inhalation) and triamcinolone acetonide administered via pressurized metered-dose inhaler (200 to 1600 μg/d) among persons treated in managed care settings. A total of 945 subjects 18 years of age or older diagnosed with asthma and enrolled in 25 managed care organizations participated in this prospective, randomized, open-label, parallel-group, 12-month study. As part of the study, subjects completed a self-administered, 17-item patient satisfaction questionnaire that addressed 4 domains: side effects, knowledge/ease of use, convenience, and overall satisfaction. Questionnaire reliability was assessed using Cronbach's alpha, and validity was examined by correlating subscale scores with symptom-free days and Medical Outcomes Study 36-Item Short-Form questionnaire and Asthma Quality of Life Questionnaire scores. The satisfaction questionnaire also included a previously validated section addressing patient compliance. Patients receiving budesonide had significantly higher scores for all four satisfaction subscales throughout the study period than did those receiving triamcinolone acetonide. Similarly, compliance scores were consistently higher for the budesonide group. The difference between the treatment groups in overall satisfaction scores at the end of the study was clinically meaningful. Patients treated with budesonide were significantly more satisfied and compliant with their inhaled corticosteroid regimen compared with patients treated with triamcinolone acetonide.
KW - Asthma
KW - Budesonide
KW - Compliance
KW - Inhaled corticosteroids
KW - Managed care setting
KW - Patient satisfaction
KW - Real life
KW - Triamcinolone acetonide
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UR - http://www.scopus.com/inward/citedby.url?scp=28744439380&partnerID=8YFLogxK
U2 - 10.1080/02770900500308312
DO - 10.1080/02770900500308312
M3 - Article
C2 - 16316872
AN - SCOPUS:28744439380
SN - 0277-0903
VL - 42
SP - 769
EP - 776
JO - Journal of Asthma
JF - Journal of Asthma
IS - 9
ER -