Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder

Fuchang Jiang; Behzad Elahi; Mohit Saxena; Ilknur Telkes; Marisa Dimarzio; Julie G. Pilitsis; Laleh Golestanirad

doi:10.1109/EMBC46164.2021.9630273

Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder

Fuchang Jiang, Behzad Elahi, Mohit Saxena, Ilknur Telkes, Marisa Dimarzio, Julie G. Pilitsis, Laleh Golestanirad^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor of optimal targeting of the relevant brain structures. Computational models can help to interpret a patient's outcome by predicting the volume of tissue activated (VTA) around DBS electrode contacts. Here we report results of a preliminary study of DBS in two patients with obsessive-compulsive disorder and show that VTA predictions, which are based on patient-specific volume conductor models, correlate with clinical outcome. Our results suggest that patient specific VTA calculation can help inform device programing to maximize therapeutic effects and minimize side effects.Clinical Relevance - Patient-specific modeling of the volume of activated tissue can predict clinical outcomes and thus, can help to optimize DBS device programing to maximize therapeutic effects.

Original language	English (US)
Title of host publication	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5889-5892
Number of pages	4
ISBN (Electronic)	9781728111797
DOIs	https://doi.org/10.1109/EMBC46164.2021.9630273
State	Published - 2021
Event	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico Duration: Nov 1 2021 → Nov 5 2021

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Country/Territory	Mexico
City	Virtual, Online
Period	11/1/21 → 11/5/21

Funding

Research supported by NIH grant R00EB021320.

ASJC Scopus subject areas

Signal Processing
Health Informatics
Computer Vision and Pattern Recognition
Biomedical Engineering

Access to Document

10.1109/EMBC46164.2021.9630273

Cite this

Jiang, F., Elahi, B., Saxena, M., Telkes, I., Dimarzio, M., Pilitsis, J. G., & Golestanirad, L. (2021). Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 (pp. 5889-5892). (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC46164.2021.9630273

Jiang, Fuchang ; Elahi, Behzad ; Saxena, Mohit et al. / Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 5889-5892 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder",

abstract = "Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor of optimal targeting of the relevant brain structures. Computational models can help to interpret a patient's outcome by predicting the volume of tissue activated (VTA) around DBS electrode contacts. Here we report results of a preliminary study of DBS in two patients with obsessive-compulsive disorder and show that VTA predictions, which are based on patient-specific volume conductor models, correlate with clinical outcome. Our results suggest that patient specific VTA calculation can help inform device programing to maximize therapeutic effects and minimize side effects.Clinical Relevance - Patient-specific modeling of the volume of activated tissue can predict clinical outcomes and thus, can help to optimize DBS device programing to maximize therapeutic effects.",

author = "Fuchang Jiang and Behzad Elahi and Mohit Saxena and Ilknur Telkes and Marisa Dimarzio and Pilitsis, {Julie G.} and Laleh Golestanirad",

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series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Jiang, F, Elahi, B, Saxena, M, Telkes, I, Dimarzio, M, Pilitsis, JG & Golestanirad, L 2021, Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. in 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 5889-5892, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021, Virtual, Online, Mexico, 11/1/21. https://doi.org/10.1109/EMBC46164.2021.9630273

Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. / Jiang, Fuchang; Elahi, Behzad; Saxena, Mohit et al.
43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 5889-5892 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Jiang, Fuchang

AU - Elahi, Behzad

AU - Saxena, Mohit

AU - Telkes, Ilknur

AU - Dimarzio, Marisa

AU - Pilitsis, Julie G.

AU - Golestanirad, Laleh

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AB - Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor of optimal targeting of the relevant brain structures. Computational models can help to interpret a patient's outcome by predicting the volume of tissue activated (VTA) around DBS electrode contacts. Here we report results of a preliminary study of DBS in two patients with obsessive-compulsive disorder and show that VTA predictions, which are based on patient-specific volume conductor models, correlate with clinical outcome. Our results suggest that patient specific VTA calculation can help inform device programing to maximize therapeutic effects and minimize side effects.Clinical Relevance - Patient-specific modeling of the volume of activated tissue can predict clinical outcomes and thus, can help to optimize DBS device programing to maximize therapeutic effects.

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Jiang F, Elahi B, Saxena M, Telkes I, Dimarzio M, Pilitsis JG et al. Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 5889-5892. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC46164.2021.9630273

Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder

Abstract

Publication series

Conference

Funding

ASJC Scopus subject areas

Access to Document

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