Patients at increased risk for late engraftment after transplantation: A novel method for their identification

R. Mick, S. F. Williams, J. D. Bitran

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The time to platelet engraftment (platelets > 50 x 109/l for 3 successive days without transfusions) is a major endpoint in treatment regimens of high dose chemotherapy and autologous stem cell rescue. A number of transplanted patients die before recovery of platelets. To include such patients appropriately in an analysis to identify prognostic factors for engraftment, a proportional odds model was employed. The outcome measure was a categorization of patients into four levels based on time to engraftment: early (0-40 days), intermediate (41-70 days), late (> 70 days) or died without engraftment. Of 45 women with advanced breast cancer who underwent high dose chemotherapy and autologous transplantation, there were: 10 early, 11 intermediate and eight late engrafters and 16 who died before platelet engraftment. Based on the proportional odds model applied to these data, four significant and independent prognostic factors for later or non-engraftment were revealed: lower numbers of mononuclear cells kg harvested (p = 0.002), lower serum albumin level (p = 0.003), prior cisplatin chemotherapy (p = 0.006), and the existence of bone marrow malignancy (p = 0.025).

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalBone Marrow Transplantation
Volume6
Issue number3
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Patients at increased risk for late engraftment after transplantation: A novel method for their identification'. Together they form a unique fingerprint.

Cite this