Patients Less Likely to Lose Weight Following a Knee Replacement: Results from the Osteoarthritis Initiative

Christine A. Pellegrini*, Jing Song, Pamela A. Semanik, Rowland W. Chang, Jungwha Lee, Abigail L. Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D. Dunlop

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. Objective The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. Methods The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study. Average annual weight changes during 1- to 2-year intervals prior to, including, and subsequent to knee replacement were categorized as loss (≥-2.5%), maintain (>-2.5% to <2.5%), and gain (≥2.5%). Weight changes across time intervals were compared using logistic regression with generalized estimating equations, adjusting for demographic, health, and knee factors. Results On average, patients lost -0.6 kg/y during the interval when the surgery was performed, but weight gain (0.9 kg/y) in the initial postoperative interval represented an overall net weight gain (0.3 kg/y) compared with presurgery. Continued weight gain (0.3 kg/y) was also seen among patients with additional follow-ups. Patients were significantly less likely to have a meaningful weight loss in the time interval immediately following the surgery compared with the interval in which the surgery took place (odds ratio, 0.37; 95% confidence interval, 0.18-0.79). Conclusions Overweight and obese patients initially lost weight during the interval including knee replacement; however, they were less likely to lose more than 2.5% of their weight in the 1 to 2 years immediately after the surgery. Knee replacement patients may benefit from weight management interventions both preoperatively and postoperatively.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalJournal of Clinical Rheumatology
Issue number7
StatePublished - Oct 1 2017


  • Osteoarthritis Initiative
  • knee osteoarthritis
  • knee replacement
  • obesity
  • surgery

ASJC Scopus subject areas

  • Rheumatology


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