Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

Barton L. Wise*, Jingbo Niu, Mei Yang, Nancy E. Lane, William Harvey, David T. Felson, Jean Hietpas, Michael Nevitt, Leena Sharma, Jim Torner, C. E. Lewis, Yuqing Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Objective: We conducted a cross-sectional study to describe the prevalence of tibiofemoral joint space narrowing (JSN) in medial and lateral compartments and assess whether it differs by sex and ethnic groups, and, if it does, to what extent such a difference is accounted for by knee malalignment. Methods: The Multicenter Osteoarthritis Study is an observational study of persons ages 50-79 years with either symptomatic knee osteoarthritis or high risk of disease. Knee radiographs were assessed for JSN in each tibiofemoral compartment. Mechanical axis angle was measured using full-extremity films. We compared the proportion of knees with medial compartment JSN and with lateral JSN between men and women, as well as between whites and African Americans, using a logistic regression model adjusting for covariates (race or sex and body mass index, age, education, and clinic site). We used generalized estimating equations to account for correlation between 2 knees within a person. Results: Of 5,202 knees (2,652 subjects), 1,532 (29.5%) had medial JSN and 427 (8.2%) had lateral JSN. Lateral JSN was more prevalent in the knees of women than in men (odds ratio [OR] 1.9, 95% confidence interval [95% CI] 1.5-2.4) and was also higher in the knees of African Americans than in whites (OR 2.4, 95% CI 1.7-3.3). Further adjustment for malalignment attenuated the OR for sex but not the OR for race. Conclusion: Women and African Americans are more likely to have lateral JSN than men and whites, respectively. Valgus malalignment may contribute to the higher prevalence in women.

Original languageEnglish (US)
Pages (from-to)847-852
Number of pages6
JournalArthritis Care and Research
Issue number6
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Rheumatology


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