Patterns of language decline in non-fluent primary progressive aphasia

C. K. Thompson*, K. J. Ballard, M. E. Tait, S. Weintraub, M. Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Language samples collected yearly for up to 11 years post-onset of symptoms from four subjects presenting with non-fluent primary progressive aphasia (PPA) were analyzed and compared with samples collected from both non-brain-damaged subjects and those with agrammatic Broca's aphasia resulting from a single left-hemisphere stroke. Extensive analysis of lexical and morphosyntactic variables in these samples revealed two patterns of expressive language decline in the PPA subjects - one resembling that seen in our agrammatic aphasic subjects - i.e. impaired production of closed-class elements and loss of sentential structures governed by these elements - and the other characterized by advancing word-retrieval difficulties. These data are relevant for patient-management purposes and, in addition, they provide information relevant to language representation and organization.

Original languageEnglish (US)
Pages (from-to)297-321
Number of pages25
Issue number4-5
StatePublished - 1997

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Language and Linguistics
  • Developmental and Educational Psychology
  • Linguistics and Language
  • Neurology
  • Clinical Neurology
  • LPN and LVN


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