Patterns of objectively measured physical activity differ between men living with and without HIV

Lacey H. Etzkorn*, Fangyu Liu, Jacek K. Urbanek, Amir S. Heravi, Jared W. Magnani, Michael W. Plankey, Joseph B. Margolich, Mallory D. Witt, Frank J. Palella, Sabina A. Haberlen, Katherine C. Wu, Wendy S. Post, Jennifer A. Schrack, Ciprian M. Crainiceanu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective:To use accelerometers to quantify differences in physical activity (PA) by HIV serostatus and HIV viral load (VL) in the Multicenter AIDS Cohort Study (MACS).Methods:MACS participants living with (PLWH, n = 631) and without (PWOH, n = 578) HIV wore an ambulatory electrocardiogram monitor containing an accelerometer for 1-14 days. PA was summarized as cumulative mean absolute deviation (MAD) during the 10 most active consecutive hours (M10), cumulative MAD during the six least active consecutive hours (L6), and daily time recumbent (DTR). PA summaries were compared by HIV serostatus and by detectability of VL (>20 vs. ≤20 copies/ml) using linear mixed models adjusted for sociodemographics, weight, height, substance use, physical function, and clinical factors.Results:In sociodemographic-adjusted models, PLWH with a detectable VL had higher L6 (β = 0.58 mg, P = 0.027) and spent more time recumbent (β = 53 min/day, P = 0.003) than PWOH. PLWH had lower M10 than PWOH (undetectable VL β = -1.62 mg, P = 0.027; detectable VL β = -1.93 mg, P = 0.12). A joint test indicated differences in average PA measurements by HIV serostatus and VL (P = 0.001). However, differences by HIV serostatus in M10 and DTR were attenuated and no longer significant after adjustment for renal function, serum lipids, and depressive symptoms.Conclusions:Physical activity measures differed significantly by HIV serostatus and VL. Higher L6 among PLWH with detectable VL may indicate reduced amount or quality of sleep compared to PLWH without detectable VL and PWOH. Lower M10 among PLWH indicates lower amounts of physical activity compared to PWOH.

Original languageEnglish (US)
Pages (from-to)1553-1562
Number of pages10
JournalAIDS
Volume36
Issue number11
DOIs
StatePublished - Sep 1 2022

Funding

Sources of Funding: Analysis of existing data was supported by grants 5T32AG000247-25 from the National Institute on Aging; 5R01HL125053-04 from the National Heart, Lung, and Blood Institute; and 5R01NS060910-12 from the National Institute of Neurological Disorders and Stroke. Data in this manuscript were collected by the MulticenterAIDS Cohort Study (MACS). MACS (Principal Investigators):Johns Hopkins University Bloomberg School of Public Health (Joseph Margolick, Todd Brown), U01-AI35042; Northwestern University (Steven Wolinsky), U01-AI35039; University of California, Los Angeles (Roger Detels, Otoniel Martinez-Maza), U01-AI35040; University of Pittsburgh (Charles Rinaldo, Jeremy Martinson), U01-AI35041; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (Lisa Jacobson, Gypsyamber D'Souza), UM1-AI35043. The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute on Deafness and Communication Disorders (NIDCD). MACS data collection is also supported by UL1- TR001079 (JHU ICTR) from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Funding also includes a Lundquist CTSI grant (UL1TR001881). Dr Ashikaga receives research funding from The Foundation Leducq Transatlantic Network of Excellence (16CVD02). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH), Johns Hopkins ICTR, or NCATS. The MACS website is located at http://aidscohortstudy.org/ .

Keywords

  • HIV
  • accelerometer
  • actigraphy
  • aging
  • circadian rhythm
  • physical activity
  • physical function
  • sedentary behavior

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology

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