Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database

Karim E. Abou-Nassar, Ann Vanderplas, Jonathan W. Friedberg, Gregory A. Abel, Joyce Niland, Maria A. Rodriguez, Myron S. Czuczman, Michael Millenson, Allison Crosby, Leo I. Gordon, Andrew D. Zelenetz, Mark Kaminski, Ann S. Lacasce*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We describe the patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the initial staging of patients with newly diagnosed grade 1-2 follicular lymphoma (FL) and its potential impact on treatment. Data were obtained from the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Patients who presented between 1 January 2001 and 30 September 2009 with newly diagnosed grade 1-2 FL, with at least 6 months of follow-up, were included. We identified 953 eligible patients and 532 (56%) underwent FDG-PET as part of initial staging. Among patients who underwent FDG-PET for initial staging, 438 (82%) received early treatment compared to 259 (61.5%) of those staged without FDG-PET (p < 0.0001). Of all patients with stage I FL (n = 100), 47% were treated with radiotherapy (RT) alone, and the choice of initial treatment strategy for stage I FL did not vary significantly by use of FDG-PET (p = 0.22). The use of FDG-PET for staging of FL is widespread and is associated with a greater proportion of patients receiving early therapy. Given the widespread use and high cost of FDG-PET, its clinical utility in stage I FL should be further evaluated.

Original languageEnglish (US)
Pages (from-to)2155-2162
Number of pages8
JournalLeukemia and Lymphoma
Volume54
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • FDG-PET imaging
  • Follicular lymphoma
  • Staging

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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