Pax 4 and 6 regulate gastrointestinal endocrine cell development

Lars Inge Larsson*, Luc St-Onge, David M. Hougaard, Beatriz Sosa-Pineda, Peter Gruss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The mechanisms behind the cell-specific and compartmentalized expression of gut and pancreatic hormones is largely unknown. We hereby report that deletion of the Pax 4 gene virtually eliminates duodenal and jejunal hormone- secreting cells, as well as serotonin and somatostatin cells of the distal stomach, while deletion of the Pax 6 gene eliminates duodenal GIP cells as well as gastrin and somatostatin cells of the distal stomach. Thus, together, these two genes regulate the differentiation of all proximal gastrointestinal endocrine cells and reflect common pathways for pancreatic and gastrointestinal endocrine cell differentiation.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalMechanisms of Development
Volume79
Issue number1-2
DOIs
StatePublished - 1998

Keywords

  • Beta2
  • Gastrointestinal development
  • Gastrointestinal hormones
  • NeuroD
  • Pax genes
  • Pdx-1

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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