@article{22cbbb7ad30c43259701535365172ccf,
title = "Pd-Catalyzed Acyl C-O Bond Activation for Selective Ring-Opening of α-Methylene-β-lactones with Amines",
abstract = "A Pd-catalyzed ring-opening of β-lactones with various types of amines (primary, secondary, and aryl) to provide β-hydroxy amides with excellent selectivity toward acyl C-O bond cleavage is reported. The utility of this protocol is demonstrated in an asymmetric kinetic resolution providing enantioenriched α-methylene-β-lactones.",
author = "Malapit, {Christian A.} and Caldwell, {Donald R.} and Nicole Sassu and Samuel Milbin and Howell, {Amy R.}",
note = "Funding Information: This paper is based upon work partially supported by the National Institutes of Health (NIH) under Grant No. R01 CA193994. Boehringer Ingelheim (BI Fellowship for C.A.M.) is acknowledged for financial support. S.M. acknowledges support from the University of Connecticut McNair Scholars program. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = apr,
day = "21",
doi = "10.1021/acs.orglett.7b00494",
language = "English (US)",
volume = "19",
pages = "1966--1969",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "8",
}