Abstract
This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.
Original language | English (US) |
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Pages (from-to) | 4142-4145 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 15 |
DOIs | |
State | Published - Aug 4 2017 |
Funding
We acknowledge financial support from NIH NIGMS (GM073836) and the Danish National Research Foundation (Carbon Dioxide Activation Center; CADIAC) for support. We also thank James Bour (University of Michigan) for helpful discussions.
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry