PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

Peter J. Newman*, Michael C. Berndt, Jack Gorski, Gilbert C. White, Suzanne Lyman, Cathy Paddock, William A. Muller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

781 Scopus citations

Abstract

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup ofthe Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalScience
Volume247
Issue number4947
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily'. Together they form a unique fingerprint.

Cite this