PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

Peter J. Newman; Michael C. Berndt; Jack Gorski; Gilbert C. White; Suzanne Lyman; Cathy Paddock; William A. Muller

doi:10.1126/science.1690453

PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

Peter J. Newman^*, Michael C. Berndt, Jack Gorski, Gilbert C. White, Suzanne Lyman, Cathy Paddock, William A. Muller

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

831 Scopus citations

Abstract

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup ofthe Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

Original language	English (US)
Pages (from-to)	1219-1222
Number of pages	4
Journal	Science
Volume	247
Issue number	4947
DOIs	https://doi.org/10.1126/science.1690453
State	Published - 1990

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title = "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily",

abstract = "An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup ofthe Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.",

author = "Newman, {Peter J.} and Berndt, {Michael C.} and Jack Gorski and White, {Gilbert C.} and Suzanne Lyman and Cathy Paddock and Muller, {William A.}",

year = "1990",

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pages = "1219--1222",

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T1 - PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

AU - Newman, Peter J.

AU - Berndt, Michael C.

AU - Gorski, Jack

AU - White, Gilbert C.

AU - Lyman, Suzanne

AU - Paddock, Cathy

AU - Muller, William A.

PY - 1990

Y1 - 1990

N2 - An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup ofthe Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

AB - An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup ofthe Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.

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JF - Science

IS - 4947

ER -

PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

Abstract

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