Pediatric, adolescent, and young adult breast and reproductive tumors

Courtney J. Harris, Erin E. Rowell, Yasmin Jayasinghe, Carrye Cost, Krista J. Childress, Natasha N. Frederick, Orla McNally, Leslie Appiah, Antoinette Anazodo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Tumors of the breast and reproductive organs that occur in children, adolescents, and young adults (AYA) have different biological features and can present special challenges. Although prognosis for these tumors is generally favorable, the long-term effects of treatment can be debilitating. Treatments are often multimodal and may include surgery as well as chemotherapy and/or radiation, which can cause considerable distress and anxiety related to loss of femininity or masculinity, concern over future fertility, or sexual dysfunction. Thus, tumors of the reproductive organs in pediatric/AYA patients require special consideration of the treatment effects beyond the intended oncologic outcome. Multidisciplinary teams should be involved in their care and address issues of fertility, sexual dysfunction, and psychosexual concerns before treatment begins. This review addresses histology, risk factors, prognosis, staging and treatment of gynecologic, breast and testicular cancers in pediatric and AYA patients.

Original languageEnglish (US)
Article numbere29422
JournalPediatric Blood and Cancer
Issue numberS5
StatePublished - Sep 2023


  • adolescent and young adult cancer
  • fertility preservation
  • pediatric cancer
  • reproductive tumors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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