TY - JOUR
T1 - Pediatric Central Nervous System Tumor Diagnosis, Complications, and Emergencies
AU - Lenzen, Alicia
AU - Garcia Sosa, Rebecca M.
AU - Habiby, Reema
AU - DiPatri, Arthur J.
AU - Smiley, Natasha Pillay
N1 - Funding Information:
Funding: A Lenzen is supported, in part, by the NIH National Center for Advancing Translational Sciences grant TL1TR001423 .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6
Y1 - 2018/6
N2 - Central nervous system tumors are the most common solid malignancy in childhood and the leading cause of cancer-related mortality in children. With an average of 13 new patients being diagnosed daily with a central nervous system tumor, many of these patients will present to the emergency department for evaluation and management. Furthermore, many children experience complications and/or adverse effects directly from the tumor itself, from multimodality treatment (ie, surgery, radiation therapy, and/or chemotherapy), and/or as long-term survivors. Oncologic emergencies include increased intracranial pressure, spinal cord compression, seizures/status epilepticus, central diabetes insipidus, and adrenal insufficiency. Evaluation and management by emergency medicine practitioners are critically important for these patients in all phases of their diagnosis and treatment and can contribute significantly to an improved prognosis.
AB - Central nervous system tumors are the most common solid malignancy in childhood and the leading cause of cancer-related mortality in children. With an average of 13 new patients being diagnosed daily with a central nervous system tumor, many of these patients will present to the emergency department for evaluation and management. Furthermore, many children experience complications and/or adverse effects directly from the tumor itself, from multimodality treatment (ie, surgery, radiation therapy, and/or chemotherapy), and/or as long-term survivors. Oncologic emergencies include increased intracranial pressure, spinal cord compression, seizures/status epilepticus, central diabetes insipidus, and adrenal insufficiency. Evaluation and management by emergency medicine practitioners are critically important for these patients in all phases of their diagnosis and treatment and can contribute significantly to an improved prognosis.
KW - adrenal insufficiency
KW - central nervous system tumor
KW - chemotherapy
KW - diabetes insipidus
KW - intracranial pressure
KW - long-term survivor
KW - radiation therapy
KW - seizures
KW - transfusion
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U2 - 10.1016/j.cpem.2018.06.003
DO - 10.1016/j.cpem.2018.06.003
M3 - Article
AN - SCOPUS:85048575761
SN - 1522-8401
VL - 19
SP - 153
EP - 161
JO - Clinical Pediatric Emergency Medicine
JF - Clinical Pediatric Emergency Medicine
IS - 2
ER -