Pediatric health-related quality of life: Feasibility, reliability and validity of the PedsQL™ transplant module

J. Weissberg-Benchell*, T. E. Zielinski, S. Rodgers, R. N. Greenley, D. Askenazi, S. L. Goldstein, E. M. Fredericks, S. McDiarmid, L. Williams, C. A. Limbers, K. Tuzinkiewicz, S. Lerret, E. M. Alonso, J. W. Varni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The measurement properties of the newly developed Pediatric Quality of Life Inventory™ (PedsQL™) 3.0 Transplant Module in pediatric solid organ transplant recipients were evaluated. Participants included pediatric recipients of liver, kidney, heart and small bowel transplantation who were cared for at seven medical centers across the United States and their parents. Three hundred and thirty-eight parents of children ages 2-18 and 274 children ages 5-18 completed both the PedsQL™ 4.0 Generic Core Scales and the Transplant Module. Findings suggest that child self-report and parent proxy-report scales on the Transplant Module demonstrated excellent reliability (total scale score for child self-report α = 0.93; total scale score for parent proxy-report α = 0.94). Transplant-specific symptoms or problems were significantly correlated with lower generic HRQOL, supporting construct validity. Childrenwith solid organ transplants and their parents reported statistically significant lower generic HRQOL than healthy children. Parent and child reports showed moderate to good agreement across the scales. In conclusion, the PedsQL™ Transplant Module demonstrated excellent initial feasibility, reliability and construct validity in pediatric patients with solid organ transplants.

Original languageEnglish (US)
Pages (from-to)1677-1685
Number of pages9
JournalAmerican Journal of Transplantation
Volume10
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Patient report outcomes
  • Pediatrics
  • PedsQL™
  • Quality of life
  • Transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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