Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas

Jason R Fangusaro*

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.

Original languageEnglish (US)
Pages (from-to)1409-1417
Number of pages9
JournalJournal of child neurology
Volume24
Issue number11
DOIs
StatePublished - Nov 12 2009

Keywords

  • Brainstem
  • Diffuse intrinsic pontine glioma
  • Glioblastoma
  • High-grade glioma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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