Abstract
Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1409-1417 |
| Number of pages | 9 |
| Journal | Journal of child neurology |
| Volume | 24 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 12 2009 |
Keywords
- Brainstem
- Diffuse intrinsic pontine glioma
- Glioblastoma
- High-grade glioma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology