Pediatric malignant germ cell tumors: A comparison of the neuro-oncology and solid tumor experience

Ashley S. Plant*, Susan N. Chi, Lindsay Frazier

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Scopus citations


Malignant germ cell tumors (GCT) arise from abnormal migration of primordial germ cells and are histologically identical whether they occur inside or outside the central nervous system (CNS). However, the treatment strategy for GCTs varies greatly depending on the location of the tumor. These differences are in part due to the increased morbidity of surgery in the CNS but may also reflect differential sensitivity of the tumors to chemotherapy and radiation therapy (RT) or not-yet-understood biologic differences between these tumors. Historically, specialists caring for extracranial and intracranial GCT in the United States have practiced separately without much cross communication. The focus of this review is a discussion of differences between the management of CNS and extra-CNS GCTs and opportunities for collaboration and future research.

Original languageEnglish (US)
Pages (from-to)2086-2095
Number of pages10
JournalPediatric Blood and Cancer
Issue number12
StatePublished - Dec 1 2016
Externally publishedYes


  • autologous stem cell transplant
  • chemotherapy
  • germ cell tumor
  • growing teratoma syndrome
  • immature teratoma
  • radiation therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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