Pediatric multiple sclerosis

E. Ann Yeh*, Tanuja Chitnis, Lauren Krupp, Jayne Ness, Dorothée Chabas, Nancy Kuntz, Emmanuelle Waubant

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field.

Original languageEnglish (US)
Pages (from-to)621-631
Number of pages11
JournalNature Reviews Neurology
Volume5
Issue number11
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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