Abstract
Pediatric reproductive development begins at fertilization with the establishment of chromosomal sex, followed by the development of the gonads and external genitalia. Puberty is the stage at which the gonads and sex organs mature, culminating in reproductive capability. Pediatric disorders of reproductive endocrinology, therefore, involve diagnoses in neonates through adolescents, representing a variety of diseases that includes disorders of sex development (DSD), precocious and delayed puberty, and hyperandrogenism in adolescents. This chapter focuses on the definition, evaluation, and management of these disorders. The field has rapidly changed in the past decade with advancements in genetic testing and the identification of genes responsible for these disorders. Additionally, the concept of oncofertility, which addresses fertility preservation in pediatric cancer survivors and those with congenital or early-onset gonadal dysfunction, is included.
Original language | English (US) |
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Title of host publication | Biochemical and Molecular Basis of Pediatric Disease |
Publisher | Elsevier |
Pages | 939-964 |
Number of pages | 26 |
ISBN (Electronic) | 9780128179628 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- Fertility preservation
- Hyperandrogenism
- Pediatric reproductive
- Puberty
- Reproductive endocrinology
- Sex development
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology