Pediatric reproductive disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pediatric reproductive development begins at fertilization with the establishment of chromosomal sex, followed by the development of the gonads and external genitalia. Puberty is the stage at which the gonads and sex organs mature, culminating in reproductive capability. Pediatric disorders of reproductive endocrinology, therefore, involve diagnoses in neonates through adolescents, representing a variety of diseases that includes disorders of sex development (DSD), precocious and delayed puberty, and hyperandrogenism in adolescents. This chapter focuses on the definition, evaluation, and management of these disorders. The field has rapidly changed in the past decade with advancements in genetic testing and the identification of genes responsible for these disorders. Additionally, the concept of oncofertility, which addresses fertility preservation in pediatric cancer survivors and those with congenital or early-onset gonadal dysfunction, is included.

Original languageEnglish (US)
Title of host publicationBiochemical and Molecular Basis of Pediatric Disease
PublisherElsevier
Pages939-964
Number of pages26
ISBN (Electronic)9780128179628
DOIs
StatePublished - Jan 1 2021

Keywords

  • Fertility preservation
  • Hyperandrogenism
  • Pediatric reproductive
  • Puberty
  • Reproductive endocrinology
  • Sex development

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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