Pediatric SepSis: Preparing for the future against a global scourge

Carley Riley; Rajit K. Basu; Niranjan Kissoon; Derek S. Wheeler

doi:10.1007/s11908-012-0281-5

Pediatric SepSis: Preparing for the future against a global scourge

Carley Riley, Rajit K. Basu, Niranjan Kissoon, Derek S. Wheeler^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Sepsis is a leading cause ofmorbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.

Original language	English (US)
Pages (from-to)	503-511
Number of pages	9
Journal	Current Infectious Disease Reports
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/s11908-012-0281-5
State	Published - Oct 2012

Keywords

Global pediatric sepsis
Pathophysiology of pediatric sepsis
Pediatric sepsis

ASJC Scopus subject areas

Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11908-012-0281-5

Cite this

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title = "Pediatric SepSis: Preparing for the future against a global scourge",

abstract = "Sepsis is a leading cause ofmorbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.",

keywords = "Global pediatric sepsis, Pathophysiology of pediatric sepsis, Pediatric sepsis",

author = "Carley Riley and Basu, {Rajit K.} and Niranjan Kissoon and Wheeler, {Derek S.}",

note = "Funding Information: Supported by AHRQ R18 HS020455",

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T2 - Preparing for the future against a global scourge

AU - Riley, Carley

AU - Basu, Rajit K.

AU - Kissoon, Niranjan

AU - Wheeler, Derek S.

N1 - Funding Information: Supported by AHRQ R18 HS020455

PY - 2012/10

Y1 - 2012/10

N2 - Sepsis is a leading cause ofmorbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.

AB - Sepsis is a leading cause ofmorbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.

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KW - Pathophysiology of pediatric sepsis

KW - Pediatric sepsis

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Pediatric SepSis: Preparing for the future against a global scourge

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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