Pediatric SLE-towards a comprehensive management plan

Hermine I. Brunner, Jennifer Huggins, Marisa S. Klein-Gitelman

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Systemic lupus erythematosus (SLE) results from complex abnormalities of the innate and acquired immune systems. For reasons that are currently not well understood, the disease course and phenotype associated with SLE, although quite variable, are generally more severe when the diagnosis is made during childhood. Active disease, infections, lupus nephritis, and neuropsychiatric SLE manifestations are associated with higher morbidity and mortality. Unlike in adult-onset SLE, systemic glucocorticoid therapy and immunosuppressive medications are needed for the treatment of the majority of children and adolescents with SLE. The complex nature of childhood-onset SLE demands a comprehensive, multidisciplinary management approach that considers the patients' growth and development, their educational needs, and the unpredictable course of SLE and its complications.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalNature Reviews Rheumatology
Issue number4
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Pediatric SLE-towards a comprehensive management plan'. Together they form a unique fingerprint.

Cite this