Pediatric super-refractory status epilepticus treated with allopregnanolone

Eileen Broomall; Jo Anne E. Natale; Michele Grimason; Joshua Goldstein; Craig M. Smith; Celia Chang; Stephen Kanes; Michael A. Rogawski; Mark S. Wainwright

doi:10.1002/ana.24295

Pediatric super-refractory status epilepticus treated with allopregnanolone

Eileen Broomall, Jo Anne E. Natale, Michele Grimason, Joshua Goldstein, Craig M. Smith, Celia Chang, Stephen Kanes, Michael A. Rogawski, Mark S. Wainwright^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic c-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with superrefractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children.

Original language	English (US)
Pages (from-to)	911-915
Number of pages	5
Journal	Annals of neurology
Volume	76
Issue number	6
DOIs	https://doi.org/10.1002/ana.24295
State	Published - Dec 1 2014

Funding

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1002/ana.24295

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title = "Pediatric super-refractory status epilepticus treated with allopregnanolone",

abstract = "Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic c-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with superrefractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children.",

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AU - Broomall, Eileen

AU - Natale, Jo Anne E.

AU - Grimason, Michele

AU - Goldstein, Joshua

AU - Smith, Craig M.

AU - Chang, Celia

AU - Kanes, Stephen

AU - Rogawski, Michael A.

AU - Wainwright, Mark S.

PY - 2014/12/1

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AB - Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic c-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with superrefractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children.

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Pediatric super-refractory status epilepticus treated with allopregnanolone

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