Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature

Amanda M. Rusk*, Meghan M. Crute, Jens Goebel, Marc G. Schecter, Anita Gupta, Ann R. Schwentker, Anita P. Sheth, Anne W. Lucky

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Trichodysplasia spinulosa is a rare disorder caused by the ubiquitous trichodysplasia spinulosa-associated polyomavirus (TSPyV) and characterized clinically by predominately centrofacial, but often generalized, folliculocentric papules with protuberant keratinaceous spines. Although seroprevalence reaches up to 70% in adult populations, TSPyV causes clinical manifestations in a small percentage of patients who are immunosuppressed. Diagnosis can be made using typical clinical and histologic features, SV40T antibody immunostaining, and PCR of various tissues including the keratinaceous spine, skin, serum, urine, and CSF. Various topical and systemic medications have demonstrated variable success. Decreasing or discontinuing immunosuppression has also been shown to improve or alleviate clinical manifestations.

Original languageEnglish (US)
Pages (from-to)1023-1029
Number of pages7
JournalPediatric dermatology
Issue number6
StatePublished - Nov 1 2020


  • pediatric
  • polyomavirus
  • transplant
  • trichodysplasia spinulosa

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature'. Together they form a unique fingerprint.

Cite this