TY - JOUR
T1 - PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients
T2 - Feasibility, reliability, and validity
AU - Varni, James W.
AU - Limbers, Christine A.
AU - Sorensen, Lisa G.
AU - Neighbors, Katie
AU - Martz, Karen
AU - Bucuvalas, John C.
AU - Alonso, Estella M.
N1 - Funding Information:
Funding This project was supported by grant number R01 HD045694 of the National Institute of Child Health and Human Development and grant number U01 DK061693 of the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health. The sponsoring agency was not involved in the collection, analysis, or interpretation of data or the generation of the report.
PY - 2011/8
Y1 - 2011/8
N2 - Objective: The PedsQL™ (Pediatric Quality of Life Inventory™) is a modular instrument designed to measure health-related quality of life and disease-specific symptoms. The PedsQL™ Cognitive Functioning Scale was developed as a brief generic symptom-specific instrument to measure cognitive functioning. The objective of the present study was to determine the feasibility, reliability, and validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients. Methods: The 6-item PedsQL™ Cognitive Functioning Scale and the PedsQL™ 4.0 Generic Core Scales were completed by pediatric liver transplant recipients ages 8-18 years (n = 215) and parents of pediatric liver transplant recipients ages 2-18 years (n = 502). Both patient self-report and parent proxy-report were available for 212 cases. The 72-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning, was completed by 100 parents and 56 teachers on a subset of patients. Results: The PedsQL™ Cognitive Functioning Scale demonstrated minimal missing responses (0.0%, child report, 0.67%, parent report), achieved excellent reliability (α = 0.88 child report, 0.94 parent report), distinguished between pediatric patients with liver transplants and healthy children supporting discriminant validity, and was significantly correlated with the PedsQL™ 4.0 Generic Core Scales and the BRIEF supporting construct and concurrent validity, respectively. Pediatric liver transplants recipients experienced cognitive functioning comparable to long-term pediatric cancer survivors. Conclusions: The results demonstrate the feasibility, reliability, discriminant, construct, and concurrent validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients.
AB - Objective: The PedsQL™ (Pediatric Quality of Life Inventory™) is a modular instrument designed to measure health-related quality of life and disease-specific symptoms. The PedsQL™ Cognitive Functioning Scale was developed as a brief generic symptom-specific instrument to measure cognitive functioning. The objective of the present study was to determine the feasibility, reliability, and validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients. Methods: The 6-item PedsQL™ Cognitive Functioning Scale and the PedsQL™ 4.0 Generic Core Scales were completed by pediatric liver transplant recipients ages 8-18 years (n = 215) and parents of pediatric liver transplant recipients ages 2-18 years (n = 502). Both patient self-report and parent proxy-report were available for 212 cases. The 72-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning, was completed by 100 parents and 56 teachers on a subset of patients. Results: The PedsQL™ Cognitive Functioning Scale demonstrated minimal missing responses (0.0%, child report, 0.67%, parent report), achieved excellent reliability (α = 0.88 child report, 0.94 parent report), distinguished between pediatric patients with liver transplants and healthy children supporting discriminant validity, and was significantly correlated with the PedsQL™ 4.0 Generic Core Scales and the BRIEF supporting construct and concurrent validity, respectively. Pediatric liver transplants recipients experienced cognitive functioning comparable to long-term pediatric cancer survivors. Conclusions: The results demonstrate the feasibility, reliability, discriminant, construct, and concurrent validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients.
KW - Cognitive functioning
KW - Executive functioning
KW - Liver transplant
KW - Pediatrics
KW - PedsQL™
KW - Quality of life
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U2 - 10.1007/s11136-010-9823-1
DO - 10.1007/s11136-010-9823-1
M3 - Article
C2 - 21184184
AN - SCOPUS:80052338400
SN - 0962-9343
VL - 20
SP - 913
EP - 921
JO - Quality of Life Research
JF - Quality of Life Research
IS - 6
ER -
