Peering into the dendritic machinery of striatal medium spiny neurons

D. James Surmeier; Nelson Spruston

doi:10.1016/j.neuron.2004.10.021

Peering into the dendritic machinery of striatal medium spiny neurons

D. James Surmeier^*, Nelson Spruston

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Striatal medium spiny neurons are principal players in the basal ganglia macrocircuits implicated in an astonishing array of psychomotor disorders, including Parkinson's disease, schizophrenia, Huntington's disease, and drug abuse. Using an elegant combination of 2-photon laser scanning microscopy and 2-photon uncaging of glutamate, Carter and Sabatini (this issue of Neuron) provide our first glimpse into the dendrites and spines of striatal medium spiny neurons. The results offer new insights into the workings of these clinically important yet mysterious neurons.

Original language	English (US)
Pages (from-to)	401-402
Number of pages	2
Journal	Neuron
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2004.10.021
State	Published - Oct 28 2004

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuron.2004.10.021

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abstract = "Striatal medium spiny neurons are principal players in the basal ganglia macrocircuits implicated in an astonishing array of psychomotor disorders, including Parkinson's disease, schizophrenia, Huntington's disease, and drug abuse. Using an elegant combination of 2-photon laser scanning microscopy and 2-photon uncaging of glutamate, Carter and Sabatini (this issue of Neuron) provide our first glimpse into the dendrites and spines of striatal medium spiny neurons. The results offer new insights into the workings of these clinically important yet mysterious neurons.",

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AB - Striatal medium spiny neurons are principal players in the basal ganglia macrocircuits implicated in an astonishing array of psychomotor disorders, including Parkinson's disease, schizophrenia, Huntington's disease, and drug abuse. Using an elegant combination of 2-photon laser scanning microscopy and 2-photon uncaging of glutamate, Carter and Sabatini (this issue of Neuron) provide our first glimpse into the dendrites and spines of striatal medium spiny neurons. The results offer new insights into the workings of these clinically important yet mysterious neurons.

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Peering into the dendritic machinery of striatal medium spiny neurons

Abstract

ASJC Scopus subject areas

UN SDGs

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