Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients

Shuping Wang, Julio C. Delgado, Eugene Ravkov, David D. Eckels, Ann Georgelas, Igor Y. Pavlov, Matthew Cusick, Kate Sebastian, Gerald J. Gleich, Lori A. Wagner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients and 20 negative control subjects were recruited and evaluated on the basis of history, skin prick testing, specific immunoglobulin E (IgE) levels, and peripheral blood mononuclear cell proliferation in response to shrimp tropomyosin or shrimp tropomyosin-derived peptides. Of the classically allergic patients by history, 59% tested positive for serum shrimp IgE antibodies. Of patients with shrimp-specific IgE in sera, 70% also had significant IgE levels specific for shrimp tropomyosin. Peripheral blood mononuclear cells from classically shrimp-allergic patients proliferated in a dose-dependent manner in response to to tropomyosin. In addition, a T-cell line derived from a shrimp-allergic patient proliferated specifically in response to tropomyosin-derived peptides. These studies suggest a strategy for immunotherapy using a tropomyosin-derived T-cell epitope vaccination.

Original languageEnglish (US)
Pages (from-to)426-431
Number of pages6
JournalHuman Immunology
Issue number4
StatePublished - Apr 2012


  • Allergy
  • Epitopes
  • Shrimp
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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