Penetrance of nafcillin into human ventricular fluid: Correlation with vcentricular pleocytosis and glucose levels

Ram Yogev, W. E. Schultz, S. B. Rosenman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Fourteen hydrocephalic pediatric patients with suspected shunt infections were studied for penetrance of nafcillin into the ventricular fluid after intravenous administration. In seven patients with bacterial ventriculitis, the concentration of nafcillin in ventricular fluid was 0.8 to 20.4% of the peak concentration in serum. In the remaining seven patients without bacterial ventriculitis, ventricular fluid levels ranged between ≤ 0.02 to 4% of peak serum concentrations. Although the degree of pleocytosis correlated poorly with penetrance, ventricular fluid glucose levels correlated inversely with penetrance of nafcillin (r = -0.7275, P < 0.001).

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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