Pentamorphone for management of postoperative pain

H. Y. Wong*, R. K. Parker, R. Fragen, P. F. White

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The efficacy, duration, and safety of the synthetic opioid pentamorphone in the treatment of acute postoperative pain were evaluated in a randomized, double-blind study of 72 patients given 0.08, 0.16, or 0.24 μg/kg of pentamorphone or a placebo intravenously in the recovery room after major abdominal or orthopedic surgery. Only patients given 0.24 μg/kg of pentamorphone experienced decreased pain intensity and increased sedation, both transient in duration. Although the two higher doses of pentamorphone delayed the patient's request for supplemental morphine, the total amount of morphine required within the first hour was not different between treatments. No acute cardiorespiratory changes were observed. Pentamorphone (0.08-0.24 μg/kg) was ineffective for treating acute postoperative pain after major surgery.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalAnesthesia and analgesia
Issue number5
StatePublished - 1991


  • analgesics, pentamorphone
  • pain, postoperative - pentamorphone

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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