TY - JOUR
T1 - Pentamorphone for management of postoperative pain
AU - Wong, H. Y.
AU - Parker, R. K.
AU - Fragen, R.
AU - White, P. F.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The efficacy, duration, and safety of the synthetic opioid pentamorphone in the treatment of acute postoperative pain were evaluated in a randomized, double-blind study of 72 patients given 0.08, 0.16, or 0.24 μg/kg of pentamorphone or a placebo intravenously in the recovery room after major abdominal or orthopedic surgery. Only patients given 0.24 μg/kg of pentamorphone experienced decreased pain intensity and increased sedation, both transient in duration. Although the two higher doses of pentamorphone delayed the patient's request for supplemental morphine, the total amount of morphine required within the first hour was not different between treatments. No acute cardiorespiratory changes were observed. Pentamorphone (0.08-0.24 μg/kg) was ineffective for treating acute postoperative pain after major surgery.
AB - The efficacy, duration, and safety of the synthetic opioid pentamorphone in the treatment of acute postoperative pain were evaluated in a randomized, double-blind study of 72 patients given 0.08, 0.16, or 0.24 μg/kg of pentamorphone or a placebo intravenously in the recovery room after major abdominal or orthopedic surgery. Only patients given 0.24 μg/kg of pentamorphone experienced decreased pain intensity and increased sedation, both transient in duration. Although the two higher doses of pentamorphone delayed the patient's request for supplemental morphine, the total amount of morphine required within the first hour was not different between treatments. No acute cardiorespiratory changes were observed. Pentamorphone (0.08-0.24 μg/kg) was ineffective for treating acute postoperative pain after major surgery.
KW - analgesics, pentamorphone
KW - pain, postoperative - pentamorphone
UR - http://www.scopus.com/inward/record.url?scp=0025736902&partnerID=8YFLogxK
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U2 - 10.1213/00000539-199105000-00015
DO - 10.1213/00000539-199105000-00015
M3 - Article
C2 - 1708214
AN - SCOPUS:0025736902
VL - 72
SP - 656
EP - 660
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 5
ER -