Peptide Amphiphiles and Methods to Electrostatically Control Bioactivity of the IKVAV Peptide Epitope

Samuel Stupp (Inventor)

Research output: Patent

Abstract

Novel peptides that promote neurite growth with therapeutic applications. #therapeutics #cns #peptide Northwestern researchers have created improved peptide amphiphiles bearing the laminin sequence IKVAV that promote neurite outgrowth. Synthesis and purification of these peptide amphiphiles is easier than with previous methods. In addition, these peptides are more soluble in salt solutions that mimic human extracellular fluids. Previous, similar amphiphiles demonstrated the ability to differentiate neuronal progenitors into neurons, promote neurite outgrowth, and reduce differentiation into astrocytes. Inventors: Joshua Goldberger Eric J. Berns Samuel I. Stupp* Applications: -Injectable therapy for acute spinal cord injury -Component of a scaffold for chronic spinal cord injury -Peripheral nerve regeneration -Therapies that promote differentiation of neuronal progenitors or stem cells for neuron replacement Advantages: -Improved synthesis and purification -Improved solubility in salt solutions similar to extracellular fluids IP Status: A patent application has been filed. Contact Information: Michael Moore, PhD Invention Manager (p) (847) 491-4645 (e) michaelmoore@northwestern.edu
Original languageEnglish
Patent number8748569
StatePublished - Nov 22 2012

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