Peptide supramolecular materials for therapeutics

Kohei Sato, Mark P. Hendricks, Liam C. Palmer, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

197 Scopus citations


Supramolecular assembly of peptide-based monomers into nanostructures offers many promising applications in advanced therapies. In this Tutorial Review, we introduce molecular designs to control the structure and potential biological function of supramolecular assemblies. An emphasis is placed on peptide-based supramolecular nanostructures that are intentionally designed to signal cells, either directly through the incorporation of amino acid sequences that activate receptors or indirectly by recruiting native signals such as growth factors. Additionally, we describe the use and future potential of hierarchical structures, such as single molecules that assemble into nanoscale fibers which then align to form macroscopic strings; the strings can then serve as scaffolds for cell growth, proliferation, and differentiation.

Original languageEnglish (US)
Pages (from-to)7539-7551
Number of pages13
JournalChemical Society Reviews
Issue number20
StatePublished - Oct 21 2018

ASJC Scopus subject areas

  • General Chemistry


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