Abstract
The unfolded protein response (UPRmt) rebalances mitochondrial protein homeostasis upon proteotoxic perturbations. Haynes et al. (2010) show that this retrograde stress signal is based on efflux of peptides derived from damaged proteins from the mitochondrial matrix to the cytosol; this initiates downstream protective responses in the nucleus to restore cellular balance.
Original language | English (US) |
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Pages (from-to) | 177-178 |
Number of pages | 2 |
Journal | Cell Metabolism |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - Mar 3 2010 |
ASJC Scopus subject areas
- Molecular Biology
- Physiology
- Cell Biology