Peptides Signal Mitochondrial Stress

Janine Kirstein-Miles, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations


The unfolded protein response (UPRmt) rebalances mitochondrial protein homeostasis upon proteotoxic perturbations. Haynes et al. (2010) show that this retrograde stress signal is based on efflux of peptides derived from damaged proteins from the mitochondrial matrix to the cytosol; this initiates downstream protective responses in the nucleus to restore cellular balance.

Original languageEnglish (US)
Pages (from-to)177-178
Number of pages2
JournalCell Metabolism
Issue number3
StatePublished - Mar 3 2010

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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