Per-6-bromo-per-2,3-dimethyl-β-cyclodextrin

David Alker*, Peter R. Ashton, Valerie D. Harding, Rainer Königer, J. Fraser Stoddart, Andrew J P White, David J. Williams

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

An efficient synthesis of the title compound, per-6-bromo-per-2,3-dimethylβ-cyclodextrin, is described, giving access to a highly soluble cyclodextrin, which may be used for further chemical modification of β-cyclodextrin. Crystals of the target compound were grown and the solid state structure was determined by X-ray crystallography, revealing a cyclodextrin derivative whose conformation deviates substantially from C7 symmetry.

Original languageEnglish (US)
Pages (from-to)9091-9094
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number48
DOIs
StatePublished - Nov 28 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Alker, D., Ashton, P. R., Harding, V. D., Königer, R., Stoddart, J. F., White, A. J. P., & Williams, D. J. (1994). Per-6-bromo-per-2,3-dimethyl-β-cyclodextrin. Tetrahedron Letters, 35(48), 9091-9094. https://doi.org/10.1016/0040-4039(94)88436-6