Per-6-substituted-per-6-deoxy β-cyclodextrins inhibit the formation of β-amyloid peptide derived soluble oligomers

Zhiqiang Wang, Lei Chang, William L Klein, Gregory R.J. Thatcher*, Duane L. Venton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Recent studies have indicated that the most important role of β-amyloid peptide (Aβ) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Aβ 1-42 neurotoxic intermediates (called ADDLs). In the present work we describe the preparation of per-6-amino-6-deoxy-β-cyclodextrins, which inhibit ADDLs formation in vitro.

Original languageEnglish (US)
Pages (from-to)3329-3333
Number of pages5
JournalJournal of Medicinal Chemistry
Volume47
Issue number13
DOIs
StatePublished - Jun 17 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'Per-6-substituted-per-6-deoxy β-cyclodextrins inhibit the formation of β-amyloid peptide derived soluble oligomers'. Together they form a unique fingerprint.

Cite this