Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms

Nicolas Daffern, Ishwar Radhakrishnan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

PAS domains are ubiquitous in biology. They perform critically important roles in sensing and transducing a wide variety of environmental signals, and through their ability to bind small-molecule ligands, have emerged as targets for therapeutic intervention. Here, we discuss our current understanding of PAS domain structure and function in the context of basic helix-loop-helix (bHLH)-PAS transcription factors and coactivators. Unlike the bHLH-PAS domains of transcription factors, those of the steroid receptor coactivator (SRC) family are poorly characterized. Recent progress for this family and for the broader bHLH-PAS proteins suggest that these domains are ripe for deeper structural and functional studies.

Original languageEnglish (US)
Article number168370
JournalJournal of Molecular Biology
Volume436
Issue number3
DOIs
StatePublished - Feb 1 2024

Keywords

  • protein-DNA interactions
  • protein–ligand interactions
  • protein–protein interactions
  • structural biology
  • transcription regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Structural Biology

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