Abstract
PAS domains are ubiquitous in biology. They perform critically important roles in sensing and transducing a wide variety of environmental signals, and through their ability to bind small-molecule ligands, have emerged as targets for therapeutic intervention. Here, we discuss our current understanding of PAS domain structure and function in the context of basic helix-loop-helix (bHLH)-PAS transcription factors and coactivators. Unlike the bHLH-PAS domains of transcription factors, those of the steroid receptor coactivator (SRC) family are poorly characterized. Recent progress for this family and for the broader bHLH-PAS proteins suggest that these domains are ripe for deeper structural and functional studies.
Original language | English (US) |
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Article number | 168370 |
Journal | Journal of Molecular Biology |
Volume | 436 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2024 |
Funding
This work was supported by a grant from the Sherman Fairchild Foundation to I.R. N.D. was supported by a Molecular Biophysics Training Program traineeship ( T32 GM008382 ).
Keywords
- protein-DNA interactions
- protein–ligand interactions
- protein–protein interactions
- structural biology
- transcription regulation
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
- Structural Biology