Per-Pass Performance Characteristics of Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Malignant Solid Pancreatic Masses in a Large Multicenter Cohort

Phillip S. Ge, Sachin Wani, Rabindra R. Watson, Alireza Sedarat, Stephen Kim, Carrie Marshall, Robert H. Wilson, Jitin Makker, Mehdi Mohamadnejad, Srinadh Komanduri, V. Raman Muthusamy*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is widely performed for the evaluation of pancreatic masses. We evaluated the performance characteristics of EUS-FNA in obtaining a diagnosis of pancreatic malignancy. Methods We performed a multicenter study of patients who underwent EUS-FNA for a solid pancreatic mass. Endoscopic ultrasound-guided FNA was standardized using a 25-gauge needle, slow-pull stylet technique for specimen acquisition, and on-site cytopathology. For the primary analysis, only malignant cytology was regarded as positive. A secondary analysis was performed in which malignant and/or suspicious cytology was regarded as positive. Results A total of 138 patients underwent EUS-FNA. In the primary analysis, the sensitivity of EUS-FNA for malignancy was 56.7% on first pass, 73.3% on second pass, 83.3% on third pass, 89.2% on fourth pass, and 90.8% on fifth pass, with no increase beyond the fifth pass. In the secondary analysis, the sensitivity was 75.0% on first pass, 89.2% on second pass, 93.3% on third pass, and 95.8% on fourth pass, with no increase beyond the fourth pass. No significant relationship was seen between lesion size and diagnostic yield. Conclusions Using a 25-gauge needle, the maximal diagnostic yield of EUS-FNA for a solid pancreatic mass is reached after 4 needle passes.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalPancreas
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • Endoscopic ultrasound
  • Fine-needle aspiration
  • Pancreatic cancer
  • Pancreatic mass
  • Tissue acquisition

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint Dive into the research topics of 'Per-Pass Performance Characteristics of Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Malignant Solid Pancreatic Masses in a Large Multicenter Cohort'. Together they form a unique fingerprint.

  • Cite this

    Ge, P. S., Wani, S., Watson, R. R., Sedarat, A., Kim, S., Marshall, C., Wilson, R. H., Makker, J., Mohamadnejad, M., Komanduri, S., & Muthusamy, V. R. (2018). Per-Pass Performance Characteristics of Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Malignant Solid Pancreatic Masses in a Large Multicenter Cohort. Pancreas, 47(3), 296-301. https://doi.org/10.1097/MPA.0000000000001003